Long-Term Incubation PrP
CWD
CWD infectivity
prion detection
prion protein
prolonged incubation
soil
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
23 Apr 2020
23 Apr 2020
Historique:
received:
10
03
2020
revised:
20
04
2020
accepted:
21
04
2020
entrez:
29
4
2020
pubmed:
29
4
2020
medline:
29
4
2020
Statut:
epublish
Résumé
Chronic wasting disease (CWD) is a contagious prion disease of cervids. The infectious agent is shed from animals at the preclinical and clinical stages of disease where it persists in the environment as a reservoir of CWD infectivity. In this study, we demonstrate that long-term incubation of CWD prions (generated from tg-mice infected with deer or elk prions) with illite, montmorillonite (Mte) and whole soils results in decreased recovery of PrP
Identifiants
pubmed: 32340296
pii: pathogens9040311
doi: 10.3390/pathogens9040311
pmc: PMC7238116
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Genome Canada
ID : the Systems Biology and Molecular Ecology of Chronic Wasting Disease
Organisme : Alberta Prion Research Institute
ID : 200900188, 201300025 and PAA13007
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