Technetium-Radiolabeled Mannose-Functionalized Gold Nanoparticles as Nanoprobes for Sentinel Lymph Node Detection.
99mTc
SPECT
gold nanoparticles
mannose
sentinel lymph node
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
23 Apr 2020
23 Apr 2020
Historique:
received:
06
03
2020
revised:
19
04
2020
accepted:
20
04
2020
entrez:
29
4
2020
pubmed:
29
4
2020
medline:
30
1
2021
Statut:
epublish
Résumé
Gold nanoparticles (AuNPs) are considered valuable nanomaterials for the design of radiolabeled nanoprobes for single-photon emission computed tomography (SPECT) imaging. Radiolabeled and functionalized AuNPs could improve lymphatic mapping by enhancing the radioactive signaling of individual particles in the sentinel node. In this study, an alternative method for functionalizing commercial AuNps with mannose is described. The chemical derivatization and biofunctionalization of AuNPs were performed with lipoic acid and mannose, respectively. Several levels of mannose were tested; the thiolate hydrazinonicotinamide-glycine-glycine-cysteine (HYNIC) molecule was also used for
Identifiants
pubmed: 32340310
pii: molecules25081982
doi: 10.3390/molecules25081982
pmc: PMC7221884
pii:
doi:
Substances chimiques
Radiopharmaceuticals
0
Technetium
7440-26-8
Gold
7440-57-5
Mannose
PHA4727WTP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
ID : DGAPA-IN104919
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