The Rheolaser Master™ and Kinexus Rotational Rheometer
Kinexus Rotational Rheometer
Poloxamer P407
Rheolaser Master™
ethosomes
niosomes
skin application
transfersomes
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
23 Apr 2020
23 Apr 2020
Historique:
received:
25
03
2020
revised:
21
04
2020
accepted:
22
04
2020
entrez:
29
4
2020
pubmed:
29
4
2020
medline:
30
1
2021
Statut:
epublish
Résumé
Poloxamer 407 copolymer is a versatile and widely used thermo-reversible material. Its use has many advantages, such as bio-adhesion, enhanced solubilization of poorly water-soluble drugs and many applications fields like oral, rectal, topical, nasal drug administration. Hydrogels made up of Poloxamer 407 are characterized by specific rheological features, which are affected by temperature, concentration and presence of other compounds. A strategic approach in topical therapeutic treatments may be the inclusion of drug delivery systems, such as ethosomes, transfersomes and niosomes, into hydrogel poloxamer formulation. The evaluation of the interaction between colloidal carriers and the Poloxamer 407 hydrogel network is essential for a suitable design of an innovative topical dosage form. For this reason, the Rheolaser Master™, based on diffusing wave spectroscopy, and a Kinexus Rotational Rheometer were used to evaluate the influence of nanocarriers on the microrheological features of hydrogels. The advantages of the Rheolaser Master™ analyzer are: (i) its ability to determine viscoelastic parameter, without altering or destroying the sample and at rest (zero shear); (ii) possibility of aging analysis on the same sample. This study provide evidence that vesicular systems do not influence the rheological features of the gel, supporting the possibility to encapsulate an innovative system into a three-dimensional network.
Identifiants
pubmed: 32340329
pii: molecules25081979
doi: 10.3390/molecules25081979
pmc: PMC7221562
pii:
doi:
Substances chimiques
Drug Carriers
0
Gels
0
Polymers
0
Poloxamer
106392-12-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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