New Approaches for Cryptococcosis Treatment.
Cryptococcus
antifungal
blood–brain barrier
central nervous system
cryptococcal meningitis
drug delivery systems
drug repurposing
nanocarriers
nanotechnology
synthetic molecules
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
23 Apr 2020
23 Apr 2020
Historique:
received:
26
02
2020
revised:
16
04
2020
accepted:
17
04
2020
entrez:
29
4
2020
pubmed:
29
4
2020
medline:
29
4
2020
Statut:
epublish
Résumé
Cryptococcosis is an important opportunistic infection and a leading cause of meningitis in patients with HIV infection. The antifungal pharmacological treatment is limited to amphotericin B, fluconazole and 5- flucytosine. In addition to the limited pharmacological options, the high toxicity, increased resistance rate and difficulty of the currently available antifungal molecules to cross the blood-brain barrier hamper the treatment. Thus, the search for new alternatives for the treatment of cryptococcal meningitis is extremely necessary. In this review, we describe the therapeutic strategies currently available, discuss new molecules with antifungal potential in different phases of clinical trials and in advanced pre-clinical phase, and examine drug nanocarriers to improve delivery to the central nervous system.
Identifiants
pubmed: 32340403
pii: microorganisms8040613
doi: 10.3390/microorganisms8040613
pmc: PMC7232457
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2017/19374-9; 2018/13877-1;2018/12149-2
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 303373/2019-9
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