Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention.
AIDS Vaccines
/ administration & dosage
Animals
Antibodies, Neutralizing
/ immunology
Clinical Trials as Topic
Disease Management
Genetic Variation
HIV Antibodies
/ immunology
HIV Infections
/ immunology
HIV-1
/ genetics
Host-Pathogen Interactions
/ immunology
Humans
Immunization, Passive
RNA, Viral
Structure-Activity Relationship
T-Lymphocytes
/ immunology
Viral Proteins
/ chemistry
HIV-1
bNAb
broadly neutralizing antibody
prevention
vaccine
viral diversity
Journal
Annual review of immunology
ISSN: 1545-3278
Titre abrégé: Annu Rev Immunol
Pays: United States
ID NLM: 8309206
Informations de publication
Date de publication:
26 04 2020
26 04 2020
Historique:
entrez:
29
4
2020
pubmed:
29
4
2020
medline:
12
8
2021
Statut:
ppublish
Résumé
Development of improved approaches for HIV-1 prevention will likely be required for a durable end to the global AIDS pandemic. Recent advances in preclinical studies and early phase clinical trials offer renewed promise for immunologic strategies for blocking acquisition of HIV-1 infection. Clinical trials are currently underway to evaluate the efficacy of two vaccine candidates and a broadly neutralizing antibody (bNAb) to prevent HIV-1 infection in humans. However, the vast diversity of HIV-1 is a major challenge for both active and passive immunization. Here we review current immunologic strategies for HIV-1 prevention, with a focus on current and next-generation vaccines and bNAbs.
Identifiants
pubmed: 32340576
doi: 10.1146/annurev-immunol-080219-023629
pmc: PMC7375352
mid: NIHMS1602842
doi:
Substances chimiques
AIDS Vaccines
0
Antibodies, Neutralizing
0
HIV Antibodies
0
RNA, Viral
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
673-703Subventions
Organisme : NIAID NIH HHS
ID : P01 AI131251
Pays : United States
Organisme : NIH HHS
ID : R01 OD024917
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI124377
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128751
Pays : United States
Organisme : NIAID NIH HHS
ID : K23 AI114381
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129797
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI126603
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI150590
Pays : United States
Références
Science. 2016 May 13;352(6287):828-33
pubmed: 27174988
Sci Transl Med. 2015 Dec 23;7(319):319ra206
pubmed: 26702094
N Engl J Med. 2012 Aug 2;367(5):423-34
pubmed: 22784038
Curr HIV/AIDS Rep. 2019 Apr;16(2):169-179
pubmed: 30903381
Cochrane Database Syst Rev. 2002;(1):CD003255
pubmed: 11869658
J Virol. 2012 Nov;86(21):11434-40
pubmed: 22896617
Nature. 2017 Aug 3;548(7665):108-111
pubmed: 28726771
Lancet. 2018 Jul 21;392(10143):232-243
pubmed: 30047376
Immunity. 2012 Sep 21;37(3):412-25
pubmed: 22999947
MAbs. 2017 Jul;9(5):792-800
pubmed: 28368743
J Exp Med. 2018 Sep 3;215(9):2311-2324
pubmed: 30072495
Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11341-E11348
pubmed: 30420517
J Virol. 2015 Jan 15;89(2):1195-204
pubmed: 25378501
AIDS Res Hum Retroviruses. 2012 Nov;28(11):1444-57
pubmed: 23035746
Lancet HIV. 2018 Aug;5(8):e438-e447
pubmed: 30025681
Am J Public Health. 2012 Nov;102(11):e34-44
pubmed: 22994247
J Infect Dis. 2012 Jul 15;206(2):258-66
pubmed: 22561365
PLoS One. 2014 Oct 22;9(10):e111085
pubmed: 25338098
Science. 2016 Sep 30;353(6307):1557-1560
pubmed: 27608668
Lancet. 2011 Jul 16;378(9787):256-68
pubmed: 21684591
J Virol. 2019 Mar 21;93(7):
pubmed: 30674626
Nat Med. 2000 Feb;6(2):200-6
pubmed: 10655110
Science. 2013 May 24;340(6135):1237874
pubmed: 23704576
Cell Rep. 2018 Oct 23;25(4):893-908.e7
pubmed: 30355496
Nature. 2009 Jan 1;457(7225):87-91
pubmed: 18997770
Science. 2016 Sep 2;353(6303):1045-1049
pubmed: 27540005
N Engl J Med. 2010 Dec 30;363(27):2587-99
pubmed: 21091279
J Virol. 2015 Mar;89(5):2659-71
pubmed: 25520506
PLoS Pathog. 2016 Jan 14;12(1):e1005369
pubmed: 26766578
PLoS Med. 2013 Dec;10(12):e1001568; discussion e1001568
pubmed: 24339751
PLoS One. 2013;8(3):e60245
pubmed: 23555935
Nature. 2011 May 26;473(7348):523-7
pubmed: 21562493
J Transl Med. 2015 Feb 15;13:60
pubmed: 25879820
Nature. 2019 Jun;570(7762):468-473
pubmed: 31142836
Nature. 2014 Jan 23;505(7484):502-8
pubmed: 24352234
Annu Rev Med. 2015;66:423-37
pubmed: 25341006
Stat Commun Infect Dis. 2017 Jan;9(1):
pubmed: 29218117
Cell. 2016 Sep 8;166(6):1459-1470.e11
pubmed: 27610570
EBioMedicine. 2018 May;31:25-35
pubmed: 29685793
J Virol. 2009 Jul;83(13):6508-21
pubmed: 19403685
Nat Med. 2016 Nov;22(11):1260-1267
pubmed: 27668936
Nature. 2013 Oct 3;502(7469):100-4
pubmed: 24025770
Lancet. 2019 Jun 15;393(10189):2428-2438
pubmed: 31056293
Nature. 2015 Jun 25;522(7557):487-91
pubmed: 25855300
Nature. 2016 Jul 28;535(7613):556-60
pubmed: 27338952
Science. 2016 May 20;352(6288):997-1001
pubmed: 27199429
Lancet. 2008 Nov 29;372(9653):1894-1905
pubmed: 19012957
Sci Transl Med. 2017 Sep 6;9(406):
pubmed: 28878010
J Virol. 2012 Sep;86(18):9583-9
pubmed: 22761379
Clin Infect Dis. 2015 Aug 15;61(4):572-80
pubmed: 25908682
Immunity. 2015 Nov 17;43(5):959-73
pubmed: 26588781
EClinicalMedicine. 2019 Jun 05;11:65-80
pubmed: 31312806
J Infect Dis. 2012 Aug 1;206(3):431-41
pubmed: 22634875
N Engl J Med. 2016 Sep 1;375(9):830-9
pubmed: 27424812
Lancet HIV. 2017 Sep;4(9):e402-e410
pubmed: 28747274
Nature. 2012 Jan 04;482(7383):89-93
pubmed: 22217938
J Infect Dis. 2007 Apr 1;195(7):951-9
pubmed: 17330784
Immunol Rev. 2017 Jan;275(1):230-244
pubmed: 28133800
Bull World Health Organ. 2004 Jun;82(6):454-61
pubmed: 15356939
Immunity. 2013 Jan 24;38(1):176-86
pubmed: 23313589
Immunol Rev. 2017 Jan;275(1):145-160
pubmed: 28133802
Nat Struct Mol Biol. 2016 Oct;23(10):906-915
pubmed: 27617431
Virology. 2008 Jan 5;370(1):130-41
pubmed: 17920095
Lancet. 2018 May 5;391(10132):1799-1829
pubmed: 29678342
Science. 2017 Apr 28;356(6336):364-365
pubmed: 28450592
J Virol. 2014 Nov;88(21):12669-82
pubmed: 25142607
CMAJ. 2018 Nov 19;190(46):E1350-E1360
pubmed: 30455270
PLoS Med. 2018 Jan 24;15(1):e1002493
pubmed: 29364886
Immunity. 2017 Jun 20;46(6):1073-1088.e6
pubmed: 28636956
PLoS Comput Biol. 2019 Jun 24;15(6):e1007083
pubmed: 31233494
Retrovirology. 2010 Mar 23;7:25
pubmed: 20331894
Lancet. 2007 Feb 24;369(9562):657-66
pubmed: 17321311
J Clin Invest. 2013 Jan;123(1):380-93
pubmed: 23221345
Science. 2019 May 3;364(6439):480-484
pubmed: 31048489
J Virol. 2018 Feb 12;92(5):
pubmed: 29237833
N Engl J Med. 2013 Nov 28;369(22):2083-92
pubmed: 24099601
Cell. 2016 Apr 7;165(2):449-63
pubmed: 26949186
PLoS One. 2013 Sep 26;8(9):e75665
pubmed: 24086607
Vaccine. 2016 Nov 11;34(47):5792-5801
pubmed: 27756485
N Engl J Med. 2012 Apr 5;366(14):1275-86
pubmed: 22475592
Cell. 2016 May 5;165(4):813-26
pubmed: 27114034
PLoS Med. 2005 Nov;2(11):e298
pubmed: 16231970
Science. 2015 Jul 10;349(6244):aac4223
pubmed: 26089353
Mol Ther. 2014 Feb;22(2):464-475
pubmed: 24166483
PLoS One. 2007 Oct 03;2(10):e984
pubmed: 17912361
Nat Med. 2010 Mar;16(3):324-8
pubmed: 20173754
Science. 2000 Apr 7;288(5463):55-6
pubmed: 10766634
Cell Host Microbe. 2019 Jan 9;25(1):59-72.e8
pubmed: 30629920
J Virol. 2015 Oct 14;90(1):76-91
pubmed: 26468542
Nature. 2011 Nov 23;480(7377):336-43
pubmed: 22113616
AIDS. 2017 Nov 13;31(17):2345-2354
pubmed: 28832407
J Exp Med. 2009 Jun 8;206(6):1253-72
pubmed: 19487423
N Engl J Med. 2018 Sep 6;379(10):979-981
pubmed: 30037297
J Virol. 2012 May;86(10):5877-84
pubmed: 22419810
Cell Rep. 2017 Oct 3;21(1):222-235
pubmed: 28978475
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10275-80
pubmed: 24982157
Immunity. 2016 Nov 15;45(5):1108-1121
pubmed: 27851912
Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17624-9
pubmed: 25422458
Science. 2016 Feb 12;351(6274):714-20
pubmed: 26797147
Sci Transl Med. 2017 Mar 15;9(381):
pubmed: 28298420
N Engl J Med. 2009 Dec 3;361(23):2209-20
pubmed: 19843557
Ann Intern Med. 2016 Mar 1;164(5):313-22
pubmed: 26833336
N Engl J Med. 2011 Aug 11;365(6):493-505
pubmed: 21767103
N Engl J Med. 2016 Nov 24;375(21):2037-2050
pubmed: 27959728
Lancet. 2016 Jan 2;387(10013):53-60
pubmed: 26364263
PLoS Pathog. 2016 Mar 30;12(3):e1005520
pubmed: 27028935
J Infect Dis. 2015 Feb 15;211(4):518-28
pubmed: 25165165
Nat Commun. 2018 May 15;9(1):1928
pubmed: 29765018
Cell. 2014 Jul 31;158(3):481-91
pubmed: 25065977
Nat Med. 2010 Mar;16(3):319-23
pubmed: 20173752
Nat Commun. 2018 Mar 28;9(1):1251
pubmed: 29593217
PLoS Pathog. 2015 Aug 12;11(8):e1005110
pubmed: 26267277
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18921-5
pubmed: 23100539
J Infect Dis. 2013 Jan 15;207(2):240-7
pubmed: 23125444
Science. 2013 Feb 22;339(6122):966-71
pubmed: 23430656
Lancet. 2008 Nov 29;372(9653):1881-1893
pubmed: 19012954
Nature. 2012 Oct 18;490(7420):417-20
pubmed: 22960785
Nat Med. 2007 Jan;13(1):100-6
pubmed: 17187074
J Virol. 2018 May 29;92(12):
pubmed: 29593050
AIDS. 2014 Jan 14;28(2):163-9
pubmed: 24361678
Cell. 2016 Jun 16;165(7):1621-1631
pubmed: 27315479
J Acquir Immune Defic Syndr. 2011 Dec 15;58(5):489-98
pubmed: 22083038
Lancet. 2013 Jun 15;381(9883):2060-2
pubmed: 23769217
Immunity. 2016 Sep 20;45(3):483-496
pubmed: 27617678
Lancet. 2013 Jun 15;381(9883):2083-90
pubmed: 23769234
PLoS One. 2013 Dec 02;8(12):e80562
pubmed: 24312481
Immunity. 2019 Jan 15;50(1):241-252.e6
pubmed: 30552025
AIDS. 2014 Jun 19;28(10):1509-19
pubmed: 24809629
J Acquir Immune Defic Syndr. 2016 Apr 1;71(4):e115-8
pubmed: 26627105
J Intern Med. 2009 Jan;265(1):67-77
pubmed: 19093961
J Transl Med. 2011 Dec 07;9:208
pubmed: 22152067
N Engl J Med. 2015 Dec 3;373(23):2237-46
pubmed: 26624850
JAMA. 2016 Jul 12;316(2):171-81
pubmed: 27404185
Mol Ther. 2016 Apr;24(4):832-42
pubmed: 26743582
MMWR Morb Mortal Wkly Rep. 2016 May 06;65(17):458
pubmed: 27149423
Nature. 2019 Apr;568(7752):415-419
pubmed: 30971821
J Infect Dis. 2013 Oct 15;208(8):1231-9
pubmed: 23878319
J Virol. 2012 Nov;86(22):12105-14
pubmed: 22933284
J Virol. 1994 Nov;68(11):7467-81
pubmed: 7933130
N Engl J Med. 2012 Aug 2;367(5):399-410
pubmed: 22784037
Lancet. 2007 Feb 24;369(9562):643-56
pubmed: 17321310
J Infect Dis. 2006 Dec 15;194(12):1650-60
pubmed: 17109336
Immunity. 2013 Aug 22;39(2):245-58
pubmed: 23911655
Nature. 2018 Sep;561(7724):479-484
pubmed: 30258136
Nat Med. 2018 Nov;24(11):1701-1707
pubmed: 30258217
Mol Ther. 2016 Feb;24(2):375-384
pubmed: 26581160
J Infect Dis. 2004 May 15;189(10):1785-92
pubmed: 15122514
Science. 2015 Jul 17;349(6245):320-4
pubmed: 26138104
Science. 2015 Jul 10;349(6244):156-61
pubmed: 26089355
PLoS Pathog. 2016 Sep 14;12(9):e1005864
pubmed: 27627672
J Infect Dis. 2017 May 1;215(9):1376-1385
pubmed: 28199679
Cell Chem Biol. 2017 Dec 21;24(12):1513-1522.e4
pubmed: 29107699
Cell Rep. 2016 Aug 30;16(9):2327-38
pubmed: 27545891
Nat Med. 2011 Mar;17(3):366-71
pubmed: 21358627
Sci Transl Med. 2017 Mar 15;9(381):
pubmed: 28298421
Curr Opin HIV AIDS. 2013 Jul;8(4):288-94
pubmed: 23666390
Nature. 2016 May 5;533(7601):105-109
pubmed: 27120156
Cell. 2015 Dec 17;163(7):1702-15
pubmed: 26687358
Nat Med. 2000 Feb;6(2):207-10
pubmed: 10655111
Curr Opin Immunol. 2018 Aug;53:143-151
pubmed: 29775847
Science. 2017 Oct 6;358(6359):85-90
pubmed: 28931639
Nature. 2014 May 1;509(7498):55-62
pubmed: 24590074
Nat Med. 2018 Jun;24(6):857-867
pubmed: 29867235
Cell. 2016 Sep 8;166(6):1445-1458.e12
pubmed: 27610569
PLoS Pathog. 2012;8(5):e1002721
pubmed: 22693447
Nat Med. 2015 Nov;21(11):1332-6
pubmed: 26457756
Cell. 2015 Nov 5;163(4):988-98
pubmed: 26544943
Immunol Rev. 2017 Jan;275(1):21-32
pubmed: 28133813
Cell. 2013 Oct 24;155(3):531-9
pubmed: 24243013
Nature. 2011 Sep 22;477(7365):466-70
pubmed: 21849977
Nat Med. 2017 Feb;23(2):185-191
pubmed: 28092665
J Virol. 2014 Nov;88(21):12623-43
pubmed: 25142591
J Infect Dis. 2018 Mar 28;217(8):1280-1288
pubmed: 29325070
Nat Immunol. 2018 Nov;19(11):1179-1188
pubmed: 30333615
Lancet HIV. 2015 Dec;2(12):e512-9
pubmed: 26614965
Nature. 2013 Apr 25;496(7446):469-76
pubmed: 23552890
Sci Transl Med. 2017 Sep 20;9(408):
pubmed: 28931655
Nat Med. 2009 Aug;15(8):951-4
pubmed: 19525965
Lancet HIV. 2018 Jul;5(7):e366-e378
pubmed: 29898870
PLoS Pathog. 2018 Mar 5;14(3):e1006860
pubmed: 29505593
PLoS Pathog. 2016 Jul 19;12(7):e1005742
pubmed: 27434311
Nat Commun. 2015 Sep 29;6:8443
pubmed: 26416571