Accumulation of Lithium in the Hippocampus of Patients With Bipolar Disorder: A Lithium-7 Magnetic Resonance Imaging Study at 7 Tesla.

Antimanic Agents / therapeutic use Bipolar Disorder / diagnostic imaging Hippocampus / diagnostic imaging Humans Lithium / therapeutic use Magnetic Resonance Imaging
Bipolar disorder (BD) Brain High magnetic field Hippocampus Lithium-7 ((7)Li) Magnetic resonance imaging (MRI)

Journal

Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264

Informations de publication

Date de publication:
01 09 2020
Historique:
received: 19 09 2019
revised: 14 01 2020
accepted: 03 02 2020
pubmed: 29 4 2020
medline: 20 2 2021
entrez: 29 4 2020
Statut: ppublish

Résumé

Lithium (Li) is a first-line treatment for bipolar disorder (BD). To study its cerebral distribution and association with plasma concentrations, we used Three-dimensional Using unprecedented spatial sensitivity and specificity, we were able to confirm the heterogeneity of the brain Li distribution and its interindividual variability, as well as the strong correlation between plasma and average brain [Li] ([Li] This observation could be of interest considering 1) the major role of the hippocampus in emotion processing and regulation, 2) the consistent atrophy of the hippocampus in untreated patients with BD, and 3) the normalization effect of Li on gray matter volumes. This study paves the way for the elucidation of the relationship between Li cerebral distribution and its therapeutic response, notably in newly diagnosed patients with BD.

Sections du résumé

BACKGROUND
Lithium (Li) is a first-line treatment for bipolar disorder (BD). To study its cerebral distribution and association with plasma concentrations, we used
METHODS
Three-dimensional
RESULTS
Using unprecedented spatial sensitivity and specificity, we were able to confirm the heterogeneity of the brain Li distribution and its interindividual variability, as well as the strong correlation between plasma and average brain [Li] ([Li]
CONCLUSIONS
This observation could be of interest considering 1) the major role of the hippocampus in emotion processing and regulation, 2) the consistent atrophy of the hippocampus in untreated patients with BD, and 3) the normalization effect of Li on gray matter volumes. This study paves the way for the elucidation of the relationship between Li cerebral distribution and its therapeutic response, notably in newly diagnosed patients with BD.

Identifiants

DOI: 10.1016/j.biopsych.2020.02.1181 PMID: 32340717
pubmed: 32340717
pii: S0006-3223(20)31293-2
doi: 10.1016/j.biopsych.2020.02.1181
pii:
doi:

Substances chimiques

Antimanic Agents 0
Lithium 9FN79X2M3F

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

426-433

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Auteurs

Jacques Stout (J)

NeuroSpin, Commissariat à l'Énergie Atomique, Paris-Saclay University, Gif-sur-Yvette, France.

Franz Hozer (F)

NeuroSpin, Commissariat à l'Énergie Atomique, Paris-Saclay University, Gif-sur-Yvette, France; Department of Psychiatry, Corentin-Celton Hospital, Assistance Publique-Hôpitaux de Paris, Issy-les-Moulineaux, France; Paris University, Paris, France; Institut National de la Santé et de la Recherche Médicale U955 Team 15 "Translational Psychiatry," Paris-East University, Créteil, France.

Arthur Coste (A)

NeuroSpin, Commissariat à l'Énergie Atomique, Paris-Saclay University, Gif-sur-Yvette, France.

Franck Mauconduit (F)

NeuroSpin, Commissariat à l'Énergie Atomique, Paris-Saclay University, Gif-sur-Yvette, France; Siemens Healthineers, Saint-Denis, France.

Nouzha Djebrani-Oussedik (N)

Saint-Louis-Lariboisière-F. Widal Hospitals, Assistance Publique-Hôpitaux de Paris, Paris, France.

Samuel Sarrazin (S)

NeuroSpin, Commissariat à l'Énergie Atomique, Paris-Saclay University, Gif-sur-Yvette, France.

Joel Poupon (J)

Saint-Louis-Lariboisière-F. Widal Hospitals, Assistance Publique-Hôpitaux de Paris, Paris, France.

Manon Meyrel (M)

Paris University, Paris, France; Saint-Louis-Lariboisière-F. Widal Hospitals, Assistance Publique-Hôpitaux de Paris, Paris, France; Institut National de la Santé et de la Recherche Médicale UMRS-1144, Paris, France.

Sandro Romanzetti (S)

Neurology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany.

Bruno Etain (B)

Paris University, Paris, France; Saint-Louis-Lariboisière-F. Widal Hospitals, Assistance Publique-Hôpitaux de Paris, Paris, France; Institut National de la Santé et de la Recherche Médicale UMRS-1144, Paris, France; FondaMental Foundation, Créteil, France.

Cécile Rabrait-Lerman (C)

NeuroSpin, Commissariat à l'Énergie Atomique, Paris-Saclay University, Gif-sur-Yvette, France.

Josselin Houenou (J)

NeuroSpin, Commissariat à l'Énergie Atomique, Paris-Saclay University, Gif-sur-Yvette, France; Institut National de la Santé et de la Recherche Médicale U955 Team 15 "Translational Psychiatry," Paris-East University, Créteil, France; Département Médico-Universitaire de Psychiatrie et d'Addictologie, Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France; FondaMental Foundation, Créteil, France.

Frank Bellivier (F)

Paris University, Paris, France; Saint-Louis-Lariboisière-F. Widal Hospitals, Assistance Publique-Hôpitaux de Paris, Paris, France; Institut National de la Santé et de la Recherche Médicale UMRS-1144, Paris, France; FondaMental Foundation, Créteil, France.

Edouard Duchesnay (E)

NeuroSpin, Commissariat à l'Énergie Atomique, Paris-Saclay University, Gif-sur-Yvette, France.

Fawzi Boumezbeur (F)

NeuroSpin, Commissariat à l'Énergie Atomique, Paris-Saclay University, Gif-sur-Yvette, France. Electronic address: fawzi.boumezbeur@cea.fr.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Antimaniacodépressifs › Accumulation of Lithium in the Hippocampus of...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Troubles bipolaires et apparentés › Trouble bipolaire › Accumulation of Lithium in the Hippocampus of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Accumulation of Lithium in the Hippocampus of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Accumulation of Lithium in the Hippocampus of...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Lithium › Accumulation of Lithium in the Hippocampus of...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Accumulation of Lithium in the Hippocampus of...