Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants.
Anticoagulants
Factor XIa (FXIa) inhibitor
Proline analogs
Thrombin (FIIa)
Thrombosis
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
15 08 2020
15 08 2020
Historique:
received:
16
12
2019
revised:
21
02
2020
accepted:
28
02
2020
pubmed:
29
4
2020
medline:
29
5
2021
entrez:
29
4
2020
Statut:
ppublish
Résumé
A series of 4, 4-disubstituted proline analogs were designed, synthesized, and tested for selective inhibition of blood coagulation factor XIa in search of new non-vitamin K antagonists based oral anticoagulants for potential prevention and treatment of thrombotic diseases. Starting from a potent thrombin (FIIa) inhibitor chemotype with FIIa IC
Identifiants
pubmed: 32340773
pii: S0960-894X(20)30150-5
doi: 10.1016/j.bmcl.2020.127072
pii:
doi:
Substances chimiques
Anticoagulants
0
Proline
9DLQ4CIU6V
Factor XIa
EC 3.4.21.27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
127072Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.