Endocytosis in Plasmodium and Toxoplasma Parasites.

Animals Antiparasitic Agents / pharmacology Artemisinins / pharmacology Drug Resistance Endocytosis / physiology Humans Plasmodium / drug effects Toxoplasma / drug effects
Plasmodium falciparum Toxoplasma gondii artemisinin endocytosis

Journal

Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034

Informations de publication

Date de publication:
06 2020
Historique:
received: 23 02 2020
revised: 25 03 2020
accepted: 26 03 2020
pubmed: 29 4 2020
medline: 1 12 2020
entrez: 29 4 2020
Statut: ppublish

Résumé

Endocytosis is critical for many functions in eukaryotic cells. Uptake of host cell cytosol, an indispensable endocytic process in malaria blood-stage parasites, has been known for a long time. However, it is only recently that the proteins involved in this process have started to emerge. Unexpectedly, some of these proteins revealed a critical role for endocytosis in artemisinin resistance. More recently, endocytosis was discovered in both intracellular and extracellular Toxoplasma gondii parasites. Here, we review these findings, compare the endolysosomal systems of Toxoplasma and Plasmodium parasites, and present current knowledge about endocytic mechanisms in apicomplexans.

Identifiants

DOI: 10.1016/j.pt.2020.03.010 PMID: 32340866
pubmed: 32340866
pii: S1471-4922(20)30075-1
doi: 10.1016/j.pt.2020.03.010
pii:
doi:

Substances chimiques

Antiparasitic Agents 0
Artemisinins 0
artemisinin 9RMU91N5K2

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

520-532

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Tobias Spielmann (T)

Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. Electronic address: spielmann@bnitm.de.

Simon Gras (S)

Lehrstuhl für Experimentelle Parasitologie, Ludwig-Maximilians-Universität, LMU, Tierärztliche Fakultät, Leopoldstr. 5, München, Germany.

Ricarda Sabitzki (R)

Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

Markus Meissner (M)

Lehrstuhl für Experimentelle Parasitologie, Ludwig-Maximilians-Universität, LMU, Tierärztliche Fakultät, Leopoldstr. 5, München, Germany. Electronic address: Markus.Meissner@lmu.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Endocytosis in Plasmodium and Toxoplasma Parasites.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Endocytosis in Plasmodium and Toxoplasma Parasites.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Artémisinines › Endocytosis in Plasmodium and Toxoplasma Parasites.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Endocytosis in Plasmodium and Toxoplasma Parasites.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Endocytose › Endocytosis in Plasmodium and Toxoplasma Parasites.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Endocytosis in Plasmodium and Toxoplasma Parasites.
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Endocytosis in Plasmodium and Toxoplasma Parasites.
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Coccidia › Eimeriida › Sarcocystidae › Toxoplasma › Endocytosis in Plasmodium and Toxoplasma Parasites.