Anidulafungin and Micafungin Concentrations in Cerebrospinal Fluid and in Cerebral Cortex.
CNS candidiasis
CNS penetration
antifungal target-site pharmacokinetics
critically ill
echinocandins
fungal meningoencephalitis
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
23 06 2020
23 06 2020
Historique:
received:
11
02
2020
accepted:
17
04
2020
pubmed:
29
4
2020
medline:
22
6
2021
entrez:
29
4
2020
Statut:
epublish
Résumé
Anidulafungin and micafungin were quantified in cerebrospinal fluid (CSF) of critically ill adults and in cerebral cortex of deceased patients. In CSF, anidulafungin levels (<0.01 to 0.66 μg/ml) and micafungin levels (<0.01 to 0.16 μg/ml) were lower than those in plasma concentrations (0.77 to 5.07 and 1.21 to 8.70 μg/ml, respectively) drawn simultaneously. In cerebral cortex, anidulafungin and micafungin levels were 0.21 to 2.34 and 0.18 to 2.88 μg/g, respectively. Thus, MIC values of several pathogenic
Identifiants
pubmed: 32340985
pii: AAC.00275-20
doi: 10.1128/AAC.00275-20
pmc: PMC7318006
pii:
doi:
Substances chimiques
Antifungal Agents
0
Echinocandins
0
Lipopeptides
0
Anidulafungin
9HLM53094I
Micafungin
R10H71BSWG
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund FWF
ID : KLI 565
Pays : Austria
Informations de copyright
Copyright © 2020 Marx et al.
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