Honey bee virus causes context-dependent changes in host social behavior.
Animals
Beekeeping
/ methods
Bees
/ genetics
Behavior, Animal
Colony Collapse
/ epidemiology
DNA Viruses
/ genetics
Dicistroviridae
/ genetics
Disease Transmission, Infectious
/ veterinary
Host-Pathogen Interactions
/ physiology
Mites
/ genetics
Pollination
RNA, Double-Stranded
Social Behavior
Virulence
honey bee
host–pathogen evolution
pathogen manipulation
virus
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
12 05 2020
12 05 2020
Historique:
pubmed:
29
4
2020
medline:
22
8
2020
entrez:
29
4
2020
Statut:
ppublish
Résumé
Anthropogenic changes create evolutionarily novel environments that present opportunities for emerging diseases, potentially changing the balance between host and pathogen. Honey bees provide essential pollination services, but intensification and globalization of honey bee management has coincided with increased pathogen pressure, primarily due to a parasitic mite/virus complex. Here, we investigated how honey bee individual and group phenotypes are altered by a virus of concern, Israeli acute paralysis virus (IAPV). Using automated and manual behavioral monitoring of IAPV-inoculated individuals, we find evidence for pathogen manipulation of worker behavior by IAPV, and reveal that this effect depends on social context; that is, within versus between colony interactions. Experimental inoculation reduced social contacts between honey bee colony members, suggesting an adaptive host social immune response to diminish transmission. Parallel analyses with double-stranded RNA (dsRNA)-immunostimulated bees revealed these behaviors are part of a generalized social immune defensive response. Conversely, inoculated bees presented to groups of bees from other colonies experienced reduced aggression compared with dsRNA-immunostimulated bees, facilitating entry into susceptible colonies. This reduction was associated with a shift in cuticular hydrocarbons, the chemical signatures used by bees to discriminate colony members from intruders. These responses were specific to IAPV infection, suggestive of pathogen manipulation of the host. Emerging bee pathogens may thus shape host phenotypes to increase transmission, a strategy especially well-suited to the unnaturally high colony densities of modern apiculture. These findings demonstrate how anthropogenic changes could affect arms races between human-managed hosts and their pathogens to potentially affect global food security.
Identifiants
pubmed: 32341145
pii: 2002268117
doi: 10.1073/pnas.2002268117
pmc: PMC7229666
doi:
Substances chimiques
RNA, Double-Stranded
0
Banques de données
Dryad
['10.5061/dryad.m63xsj3z8']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
10406-10413Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM117467
Pays : United States
Commentaires et corrections
Type : CommentIn
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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