Juvenile Granulosa Cell Tumor with an Unusual Clinical Course: A Late-onset and Late Recurrent Case.
adult granulosa cell tumor
juvenile granulosa cell tumor
late recurrence
Journal
Acta medica Okayama
ISSN: 0386-300X
Titre abrégé: Acta Med Okayama
Pays: Japan
ID NLM: 0417611
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
29
4
2020
pubmed:
29
4
2020
medline:
14
1
2021
Statut:
ppublish
Résumé
Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (～97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.
Substances chimiques
FOXL2 protein, human
0
Forkhead Box Protein L2
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
159-163Déclaration de conflit d'intérêts
No potential conflict of interest relevant to this article was reported.
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