Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia.
brain pathologies
cognitive reserve
dementia
mild cognitive impairment
population-based cohort study
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
11
09
2019
revised:
02
02
2020
accepted:
21
02
2020
pubmed:
29
4
2020
medline:
4
6
2021
entrez:
29
4
2020
Statut:
ppublish
Résumé
The association of lifespan cognitive reserve (CR) with mild cognitive impairment (MCI) remains controversial. We aimed to examine the association of lifespan CR indicator with the risk of MCI and its progression to dementia, taking brain pathologies into account. In a community-based cohort study (mean age, 79 years) with annual follow-up (median, 5.16 years; maximum, 20 years), a cognitively intact group (n = 1182) and an MCI group (n = 420) were identified at baseline. During the follow-up, 611 participants died and underwent autopsies. CR indicator encompassing education, early life to late-life cognitive and social activities were obtained and tertiled. The multi-adjusted hazard ratio (HR) of MCI was 0.72 (95% confidence interval [CI] 0.58 to 0.90) in the cognitively intact group, and the HR of dementia was 0.66 (95% CI 0.45 to 0.97) in the MCI group for participants with the highest CR indicator (reference: the lowest CR indicator). Among MCI participants with brain pathologies, dementia incidence was about 50% lower in people with the highest CR indicator than the lowest CR indicator. High lifespan CR indicator reduces risk of MCI, and delays its progression to dementia.
Identifiants
pubmed: 32342664
doi: 10.1002/alz.12085
pmc: PMC10321560
mid: NIHMS1847385
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
873-882Subventions
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States
Organisme : NINDS NIH HHS
ID : UH2 NS100599
Pays : United States
Organisme : NIH HHS
ID : R01AG17917
Pays : United States
Organisme : NIH HHS
ID : UH2NS100599
Pays : United States
Informations de copyright
© 2020 Karolinska Institutet. Alzheimer&s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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