Affinity-Driven Design of Cargo-Switching Nanoparticles to Leverage a Cholesterol-Rich Microenvironment for Atherosclerosis Therapy.
atherosclerosis
cargo-switching
cholesterol
microenvironment
nanoparticle
Journal
ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589
Informations de publication
Date de publication:
23 06 2020
23 06 2020
Historique:
pubmed:
29
4
2020
medline:
15
5
2021
entrez:
29
4
2020
Statut:
ppublish
Résumé
Atherosclerotic plaques exhibit high deposition of cholesterol and macrophages. These are not only the main components of the plaques but also key inflammation-triggering sources. However, no existing therapeutics can achieve effective removal of both components within the plaques. Here, we report cargo-switching nanoparticles (CSNP) that are physicochemically designed to bind to cholesterol and release anti-inflammatory drug in the plaque microenvironment. CSNP have a core-shell structure with a core composed of an inclusion complex of methyl-β-cyclodextrin (cyclodextrin) and simvastatin (statin), and a shell of phospholipids. Upon interaction with cholesterol, which has higher affinity to cyclodextrin than statin, CSNP release statin and scavenge cholesterol instead through cargo-switching. CSNP exhibit cholesterol-sensitive multifaceted antiatherogenic functions attributed to statin release and cholesterol depletion
Identifiants
pubmed: 32343121
doi: 10.1021/acsnano.9b08216
pmc: PMC8543299
mid: NIHMS1748113
doi:
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6519-6531Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL119798
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139757
Pays : United States
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