Full-length genomic sequencing and characterization of Borna disease virus 1 isolates: Lessons in epidemiology.
Borna disease virus 1
apoptosis
genomic sequencing
phylogenetic analysis
proliferation
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
15
10
2019
accepted:
17
04
2020
medline:
29
4
2020
pubmed:
29
4
2020
entrez:
29
4
2020
Statut:
ppublish
Résumé
Borna disease virus 1 (BoDV-1) is a nonsegmented, negative-strand RNA virus that infects mammals including humans. BoDV-1 strains occur globally, dominate the species Mammalian 1 bornavirus, and display highly conserved genomes and persistent infection (brain, blood). Subclinical infections prevail but the rare fatal outcomes even in people need awareness and risk assessment. Although BoDV-1 strains were successfully isolated, only limited full genomic sequences are available. In this study, the entire genomes of two natural BoDV-1 isolates (Hu-H2, Equ-Cres) and one vaccine strain (DessVac) were sequenced. They were compared with 20 genomes and 20 single-gene sequences (N and P) of worldwide human strains from psychiatric and neurologic patients and animal strains from horses with Borna disease available at GenBank. Phylogenetic analyses confirmed a low divergence not exceeding 5.55%, 5.34%, and 4.94% at the genome, P-gene, and N-gene level, respectively, characteristic of BoDV-1. Human viruses tended to cluster at the country level but appeared to be independent of hosts' diseases and/or time of isolation. Notably, our data also indicated that human viruses provided individual genetic signatures but exhibited no distinct genotypes that separated them from animal strains. Sequence similarities thus occurred between different host species and distant geographic regions, supporting global BoDV-1 prevalence. Overall low genetic divergence among BoDV-1 viruses shown here also argued against zoonotic concepts, requiring further clarification beyond sequence similarities. Finally, unlike shared sequence conservation, phenotyping of natural and laboratory variants revealed that they manipulated host cells differently, underpinning the authenticity of the human BoDV-1 strains.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3125-3137Subventions
Organisme : National Key Research and Development Program of China
ID : 2017Y
Organisme : National Key Research and Development Program of China
ID : FA0505700
Organisme : Chongqing Basic and Frontier Research Project
ID : cstc2016jcyjA0159
Organisme : National Natural Science Foundation of China
ID : 81601207
Informations de copyright
© 2020 Wiley Periodicals LLC.
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