A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels.
Journal
PLoS computational biology
ISSN: 1553-7358
Titre abrégé: PLoS Comput Biol
Pays: United States
ID NLM: 101238922
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
05
08
2019
accepted:
03
02
2020
revised:
14
05
2020
pubmed:
29
4
2020
medline:
15
7
2020
entrez:
29
4
2020
Statut:
epublish
Résumé
Mechanical interactions between flowing and coagulated blood (thrombus) are crucial in dictating the deformation and remodeling of a thrombus after its formation in hemostasis. We propose a fully-Eulerian, three-dimensional, phase-field model of thrombus that is calibrated with existing in vitro experimental data. This phase-field model considers spatial variations in permeability and material properties within a single unified mathematical framework derived from an energy perspective, thereby allowing us to study effects of thrombus microstructure and properties on its deformation and possible release of emboli under different hemodynamic conditions. Moreover, we combine this proposed thrombus model with a particle-based model which simulates the initiation of the thrombus. The volume fraction of a thrombus obtained from the particle simulation is mapped to an input variable in the proposed phase-field thrombus model. The present work is thus the first computational study to integrate the initiation of a thrombus through platelet aggregation with its subsequent viscoelastic responses to various shear flows. This framework can be informed by clinical data and potentially be used to predict the risk of diverse thromboembolic events under physiological and pathological conditions.
Identifiants
pubmed: 32343724
doi: 10.1371/journal.pcbi.1007709
pii: PCOMPBIOL-D-19-01313
pmc: PMC7224566
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1007709Subventions
Organisme : NHLBI NIH HHS
ID : U01 HL116323
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL142518
Pays : United States
Déclaration de conflit d'intérêts
No authors have competing interests.
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