TAOK1 positively regulates TLR4-induced inflammatory responses by promoting ERK1/2 activation in macrophages.
ERK1/2
Inflammation
TAOK1
TLR
TPL2
TRAF6
Journal
Molecular immunology
ISSN: 1872-9142
Titre abrégé: Mol Immunol
Pays: England
ID NLM: 7905289
Informations de publication
Date de publication:
25 Apr 2020
25 Apr 2020
Historique:
received:
17
12
2019
revised:
08
04
2020
accepted:
10
04
2020
pubmed:
29
4
2020
medline:
29
4
2020
entrez:
29
4
2020
Statut:
aheadofprint
Résumé
Thousand and one amino acid kinase 1 (TAOK1) is a member of Ste20-like kinases, but its function in regulating inflammatory responses remains largely unknown. In this study, we identify TAOK1 as a positive regulator of TLR4-triggered inflammatory responses in macrophages. TAOK1 increases LPS-induced production of pro-inflammatory cytokine such as IL-6, TNF-α and IL12p40 in macrophages. TAOK1 deficient mice showed decreased susceptibility to endotoxin shock, with less pro-inflammatory cytokine production than control mice. TAOK1 promotes LPS-induced activation of ERK1/2 by constitutively interacting with TRAF6 and TPL2. These finding unravel the important role of TAOK1 as a positive regulator of TLR4-induced inflammatory responses.
Identifiants
pubmed: 32344244
pii: S0161-5890(19)30890-9
doi: 10.1016/j.molimm.2020.04.006
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
124-131Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.