Assessment of endocrine-disrupting effects of emerging polyhalogenated carbazoles (PHCZs): In vitro, in silico, and in vivo evidence.
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
11
12
2019
revised:
07
04
2020
accepted:
07
04
2020
pubmed:
29
4
2020
medline:
15
12
2020
entrez:
29
4
2020
Statut:
ppublish
Résumé
Polyhalogenated carbazoles (PHCZs) are an emerging class of persistent, bioaccumulative compounds that are structurally and chemically related to dioxins. They have been detected widely in sediment, river, and soil samples, but their environmental risks are largely unknown. Therefore, seven common PHCZs were tested for their endocrine disrupting potential in silico, in vitro, and in vivo. A dual-luciferase reporter gene assay was used to detect receptor-mediated (agonist or antagonistic) activity (concentration range: 10
Identifiants
pubmed: 32344252
pii: S0160-4120(19)34671-9
doi: 10.1016/j.envint.2020.105729
pii:
doi:
Substances chimiques
Carbazoles
0
Dioxins
0
Endocrine Disruptors
0
Estrogen Receptor alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105729Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.