Changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: A nationwide clinical study.

Aged Body Weight Breast Neoplasms / psychology Cohort Studies Female Humans Middle Aged Neoplasm Staging Obesity / psychology Patient Reported Outcome Measures Quality of Life Weight Loss

Breast cancer Health-related quality-of-life Obesity Patient-reported outcomes Survivorship Weight change Weight loss

Journal

Breast (Edinburgh, Scotland)

ISSN: 1532-3080

Titre abrégé: Breast

Pays: Netherlands

ID NLM: 9213011

Informations de publication

Date de publication:
Aug 2020

Historique:

received: 19 12 2019

revised: 11 03 2020

accepted: 06 04 2020

pubmed: 29 4 2020

medline: 20 3 2021

entrez: 29 4 2020

Statut: ppublish

Résumé

Evidence on how weight loss correlates to health-related quality-of-life (HRQOL) among obese breast cancer (BC) patients is limited. We aimed to evaluate associations between weight changes and HRQOL. We included 993 obese women with stage I-II-III BC from CANTO, a multicenter, prospective cohort collecting longitudinal, objectively-assessed anthropometric measures and HRQOL data (NCT01993498). Associations between weight changes (±5% between diagnosis and post-treatment [shortly after completion of surgery, adjuvant chemo- or radiation-therapy]) and patient-reported HRQOL (EORTC QLQ-C30/B23) were comprehensively evaluated. Changes in HRQOL and odds of severely impaired HRQOL were assessed using multivariable generalized estimating equations and logistic regression, respectively. 14.1% women gained weight, 67.3% remained stable and 18.6% lost weight. Significant decreases in functional status and exacerbation of symptoms were observed overall post-treatment. Compared to gaining weight or remaining stable, obese women who lost weight experienced less of a decline in HRQOL, reporting better physical function (mean change [95%CI] for gain, stability and loss: -12.9 [-16.5,-9.3], -6.9 [-8.2,-5.5] and -6.2 [-8.7,-3.7]; p This large contemporary study suggests that weight loss among obese BC patients during early survivorship was associated with better patient-reported outcomes, without evidence of worsened functionality or symptomatology in any domain of HRQOL.

Sections du résumé

BACKGROUND BACKGROUND

METHODS METHODS

We included 993 obese women with stage I-II-III BC from CANTO, a multicenter, prospective cohort collecting longitudinal, objectively-assessed anthropometric measures and HRQOL data (NCT01993498). Associations between weight changes (±5% between diagnosis and post-treatment [shortly after completion of surgery, adjuvant chemo- or radiation-therapy]) and patient-reported HRQOL (EORTC QLQ-C30/B23) were comprehensively evaluated. Changes in HRQOL and odds of severely impaired HRQOL were assessed using multivariable generalized estimating equations and logistic regression, respectively.

RESULTS RESULTS

14.1% women gained weight, 67.3% remained stable and 18.6% lost weight. Significant decreases in functional status and exacerbation of symptoms were observed overall post-treatment. Compared to gaining weight or remaining stable, obese women who lost weight experienced less of a decline in HRQOL, reporting better physical function (mean change [95%CI] for gain, stability and loss: -12.9 [-16.5,-9.3], -6.9 [-8.2,-5.5] and -6.2 [-8.7,-3.7]; p

CONCLUSIONS CONCLUSIONS

This large contemporary study suggests that weight loss among obese BC patients during early survivorship was associated with better patient-reported outcomes, without evidence of worsened functionality or symptomatology in any domain of HRQOL.

Identifiants

DOI: 10.1016/j.breast.2020.04.002 PMID: 32344296 PMC: PMC7375600

pubmed: 32344296

pii: S0960-9776(20)30089-8

doi: 10.1016/j.breast.2020.04.002

pmc: PMC7375600

pii:

doi:

Types de publication

Clinical Study Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

Pagination

23-32

Subventions

Organisme : NCI NIH HHS

ID : P30 CA008748

Pays : United States

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interest.

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