MiR-3613-3p from carcinoma-associated fibroblasts exosomes promoted breast cancer cell proliferation and metastasis by regulating SOCS2 expression.
Breast Neoplasms
/ genetics
Cancer-Associated Fibroblasts
/ metabolism
Carcinogenesis
/ genetics
Cell Communication
/ genetics
Cell Movement
/ genetics
Cell Proliferation
/ genetics
Exosomes
/ genetics
Female
Gene Expression Regulation, Neoplastic
Humans
MCF-7 Cells
MicroRNAs
/ genetics
Neoplasm Metastasis
Suppressor of Cytokine Signaling Proteins
/ genetics
SOCS2
breast cancer
exosomes
fibroblasts
metastasis
miR-3613-3p
Journal
IUBMB life
ISSN: 1521-6551
Titre abrégé: IUBMB Life
Pays: England
ID NLM: 100888706
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
20
03
2020
accepted:
07
04
2020
pubmed:
29
4
2020
medline:
24
11
2021
entrez:
29
4
2020
Statut:
ppublish
Résumé
Exosomes carrying microRNAs (miRNAs) mediate cell-to-cell communication, which play important roles in cancer growth and progression. However, the roles and molecular mechanisms of the miRNAs in the exosomes from carcinoma-associated fibroblasts (CAFs) are still not clear. The miRNA array showed that miR-3613-3p was an upregulated miRNA in CAFs exosomes. It was verified that miR-3613-3p was upregulated in exosomes from fibroblasts educated by TGF-β1 and the fibroblasts from breast cancer tissues. Exosomal miR-3613-3p promoted breast cancer cell proliferation and metastasis. The cellular functions showed that miR-3613-3p downregulation in the CAFs exosomes suppressed cell proliferation and metastasis in breast cancer by targeting SOCS2 expression. The clinical data showed that miR-3613-3p levels were negatively related to SOCS2 expression in breast cancer tissues. In a conclusion, the study demonstrated that activated fibroblasts exosomes with high levels of miR-3613-3p played an oncogenic role in breast cancer cell survival and metastasis, which suggested that miR-3613-3p function as a therapeutic target.
Substances chimiques
MIRN3613 microRNA, human
0
MicroRNAs
0
SOCS2 protein, human
0
Suppressor of Cytokine Signaling Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1705-1714Informations de copyright
© 2020 International Union of Biochemistry and Molecular Biology.
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