Identification of Age-Specific and Common Key Regulatory Mechanisms Governing Eggshell Strength in Chicken Using Random Forests.
Random Forests
chicken
eggshell strength
feature selection
master regulators
over-represented pathways
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
24 04 2020
24 04 2020
Historique:
received:
16
03
2020
revised:
08
04
2020
accepted:
21
04
2020
entrez:
30
4
2020
pubmed:
30
4
2020
medline:
27
3
2021
Statut:
epublish
Résumé
In today's chicken egg industry, maintaining the strength of eggshells in longer laying cycles is pivotal for improving the persistency of egg laying. Eggshell development and mineralization underlie a complex regulatory interplay of various proteins and signaling cascades involving multiple organ systems. Understanding the regulatory mechanisms influencing this dynamic trait over time is imperative, yet scarce. To investigate the temporal changes in the signaling cascades, we considered eggshell strength at two different time points during the egg production cycle and studied the genotype-phenotype associations by employing the Random Forests algorithm on chicken genotypic data. For the analysis of corresponding genes, we adopted a well established systems biology approach to delineate gene regulatory pathways and master regulators underlying this important trait. Our results indicate that, while some of the master regulators (
Identifiants
pubmed: 32344666
pii: genes11040464
doi: 10.3390/genes11040464
pmc: PMC7230204
pii:
doi:
Substances chimiques
Avian Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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