The Anti-Inflammatory and Antioxidant Effects of Sodium Propionate.
Animals
Anti-Inflammatory Agents
/ pharmacology
Antioxidants
/ pharmacology
Cyclooxygenase 2
/ metabolism
Hydrogen Peroxide
/ metabolism
Inflammation
/ drug therapy
Lipopolysaccharides
/ immunology
Male
Mice
NF-kappa B
/ metabolism
Nitric Oxide
/ metabolism
Nitric Oxide Synthase Type II
/ metabolism
Oxidative Stress
/ drug effects
Peroxidase
/ metabolism
Propionates
/ pharmacology
Rats
NF-κB
SCFAs
SP
inflammation
oxidative stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Apr 2020
24 Apr 2020
Historique:
received:
02
04
2020
revised:
19
04
2020
accepted:
21
04
2020
entrez:
30
4
2020
pubmed:
30
4
2020
medline:
2
2
2021
Statut:
epublish
Résumé
The major end-products of dietary fiber fermentation by gut microbiota are the short-chain fatty acids (SCFAs) acetate, propionate, and butyrate, which have been shown to modulate host metabolism via effects on metabolic pathways at different tissue sites. Several studies showed the inhibitory effects of sodium propionate (SP) on nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. We carried out an in vitro model of inflammation on the J774-A1 cell line, by stimulation with lipopolysaccharide (LPS) and H
Identifiants
pubmed: 32344758
pii: ijms21083026
doi: 10.3390/ijms21083026
pmc: PMC7215993
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antioxidants
0
Lipopolysaccharides
0
NF-kappa B
0
Propionates
0
Nitric Oxide
31C4KY9ESH
Hydrogen Peroxide
BBX060AN9V
sodium propionate
DK6Y9P42IN
Peroxidase
EC 1.11.1.7
Nitric Oxide Synthase Type II
EC 1.14.13.39
Cyclooxygenase 2
EC 1.14.99.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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