The Effects of Human BDH2 on the Cell Cycle, Differentiation, and Apoptosis and Associations with Leukemia Transformation in Myelodysplastic Syndrome.
Adult
Aged
Aged, 80 and over
Apoptosis
/ genetics
Bone Marrow
/ metabolism
Cell Cycle Checkpoints
/ genetics
Cell Differentiation
/ genetics
Female
Ferritins
/ blood
Gene Expression Regulation
/ genetics
Gene Expression Regulation, Leukemic
Humans
Hydroxybutyrate Dehydrogenase
/ biosynthesis
Leukemia, Myeloid, Acute
/ enzymology
Lipocalin-2
/ biosynthesis
Male
Middle Aged
Myelodysplastic Syndromes
/ blood
Neoplasm Proteins
/ biosynthesis
Preleukemia
/ enzymology
Prognosis
Progression-Free Survival
RNA Interference
RNA, Messenger
/ biosynthesis
RNA, Neoplasm
/ biosynthesis
RNA, Small Interfering
/ genetics
THP-1 Cells
Young Adult
BDH2
LCN2
acute leukemia
iron metabolism
myelodysplastic syndrome (MDS)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Apr 2020
25 Apr 2020
Historique:
received:
18
03
2020
revised:
22
04
2020
accepted:
23
04
2020
entrez:
30
4
2020
pubmed:
30
4
2020
medline:
4
2
2021
Statut:
epublish
Résumé
Iron overload is related to leukemia transformation in myelodysplastic syndrome (MDS) patients. Siderophores help to transport iron. Type 2-hydroxybutyrate dehydrogenase (BDH2) is a rate-limiting factor in the biogenesis of siderophores. Using qRT-PCR, we analyze
Identifiants
pubmed: 32344823
pii: ijms21093033
doi: 10.3390/ijms21093033
pmc: PMC7246807
pii:
doi:
Substances chimiques
LCN2 protein, human
0
Lipocalin-2
0
Neoplasm Proteins
0
RNA, Messenger
0
RNA, Neoplasm
0
RNA, Small Interfering
0
Ferritins
9007-73-2
BDH2 protein, human
EC 1.1.1.30
Hydroxybutyrate Dehydrogenase
EC 1.1.1.30
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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