Nonstructural NS5A Protein Regulates LIM and SH3 Domain Protein 1 to Promote Hepatitis C Virus Propagation.
Cytoskeletal Proteins
/ genetics
Gene Expression Regulation
Gene Knockdown Techniques
HEK293 Cells
Hepacivirus
/ physiology
Hepatitis C
/ transmission
Homeodomain Proteins
/ genetics
Humans
LIM Domain Proteins
/ genetics
Protein Array Analysis
Protein Binding
Protein Domains
/ genetics
Viral Nonstructural Proteins
/ genetics
Virus Replication
LASP-1
NS5A
hepatitis C virus
protein microarray
viral replication
Journal
Molecules and cells
ISSN: 0219-1032
Titre abrégé: Mol Cells
Pays: Korea (South)
ID NLM: 9610936
Informations de publication
Date de publication:
31 May 2020
31 May 2020
Historique:
received:
14
01
2020
revised:
26
02
2020
accepted:
20
03
2020
pubmed:
30
4
2020
medline:
12
11
2020
entrez:
30
4
2020
Statut:
ppublish
Résumé
Hepatitis C virus (HCV) propagation is highly dependent on cellular proteins. To identify the host factors involved in HCV propagation, we previously performed protein microarray assays and identified the LIM and SH3 domain protein 1 (LASP-1) as an HCV NS5A-interacting partner. LASP-1 plays an important role in the regulation of cell proliferation, migration, and protein-protein interactions. Alteration of LASP-1 expression has been implicated in hepatocellular carcinoma. However, the functional involvement of LASP1 in HCV propagation and HCV-induced pathogenesis has not been elucidated. Here, we first verified the protein interaction of NS5A and LASP-1 by both
Identifiants
pubmed: 32344996
pii: molcells.2020.0018
doi: 10.14348/molcells.2020.0018
pmc: PMC7264479
doi:
Substances chimiques
Cytoskeletal Proteins
0
Homeodomain Proteins
0
LIM Domain Proteins
0
Lasp1 protein, mouse
0
Viral Nonstructural Proteins
0
NS-5 protein, hepatitis C virus
EC 2.7.7.48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
469-478Références
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