Self-reactive T cells induce and perpetuate chronic relapsing arthritis.
Adoptive T cell transfer
Chronic arthritis
MHC class II
PIA
Pristane
RA
T cell depletion
Journal
Arthritis research & therapy
ISSN: 1478-6362
Titre abrégé: Arthritis Res Ther
Pays: England
ID NLM: 101154438
Informations de publication
Date de publication:
28 04 2020
28 04 2020
Historique:
received:
12
09
2019
accepted:
13
01
2020
entrez:
30
4
2020
pubmed:
30
4
2020
medline:
13
4
2021
Statut:
epublish
Résumé
CD4 We used the rat pristane-induced arthritis model, which accurately portrays the chronic relapsing-remitting disease course of RA, to examine the contribution of T cells to chronic arthritis. Rats subjected to whole-body irradiation and injected with CD4 These findings show that, once activated, self-reactive T cells can sustain inflammatory responses for extended periods of time and suggest that such responses are promoted in the presence of IL-17.
Sections du résumé
BACKGROUND
CD4
METHODS
We used the rat pristane-induced arthritis model, which accurately portrays the chronic relapsing-remitting disease course of RA, to examine the contribution of T cells to chronic arthritis.
RESULTS
Rats subjected to whole-body irradiation and injected with CD4
CONCLUSION
These findings show that, once activated, self-reactive T cells can sustain inflammatory responses for extended periods of time and suggest that such responses are promoted in the presence of IL-17.
Identifiants
pubmed: 32345366
doi: 10.1186/s13075-020-2104-7
pii: 10.1186/s13075-020-2104-7
pmc: PMC7187533
doi:
Substances chimiques
Interleukin-17
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
95Références
Nat Genet. 2010 Jun;42(6):508-14
pubmed: 20453842
Arthritis Res. 2000;2(5):374-8
pubmed: 11094451
Eur J Immunol. 1991 May;21(5):1327-30
pubmed: 1828032
J Biol Chem. 1985 Apr 25;260(8):4839-44
pubmed: 2580828
Arthritis Rheum. 1986 Jan;29(1):106-13
pubmed: 3947407
Science. 1999 Nov 26;286(5445):1732-5
pubmed: 10576739
Clin Exp Immunol. 1982 Jul;49(1):22-30
pubmed: 6751631
J Immunol. 2007 Dec 1;179(11):7568-76
pubmed: 18025202
Am J Hum Genet. 2005 Dec;77(6):1044-60
pubmed: 16380915
J Immunol. 2008 Mar 15;180(6):3910-8
pubmed: 18322199
Arthritis Rheum. 2012 Aug;64(8):2537-47
pubmed: 22391806
Eur J Immunol. 2017 Mar;47(3):563-574
pubmed: 28012172
Arthritis Rheum. 2002 Jan;46(1):259-68
pubmed: 11817600
J Immunol Methods. 2008 Mar 20;332(1-2):170-4
pubmed: 18164026
J Immunol. 2008 Jun 1;180(11):7305-17
pubmed: 18490730
Cell. 1996 Nov 29;87(5):811-22
pubmed: 8945509
Ann Rheum Dis. 2013 Jul;72(7):1225-32
pubmed: 23041839
J Immunol. 2006 Jul 1;177(1):192-200
pubmed: 16785514
J Immunol. 2006 Jan 15;176(2):1172-9
pubmed: 16394006
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14005-10
pubmed: 18779593
Blood. 2012 Sep 20;120(12):2417-27
pubmed: 22806892
Nature. 2014 Feb 20;506(7488):376-81
pubmed: 24390342
Clin Exp Immunol. 1998 Mar;111(3):521-6
pubmed: 9528892
Nat Genet. 2012 Mar 25;44(5):511-6
pubmed: 22446963
PLoS Med. 2006 Sep;3(9):e348
pubmed: 16968121
Arthritis Rheum. 2009 Jul;60(7):1944-56
pubmed: 19565497
Ann Inst Pasteur Immunol (1985). 1986 May-Jun;137C(3):313-28
pubmed: 3527032
Ann Rheum Dis. 2002 Nov;61 Suppl 2:ii43-5
pubmed: 12379620
Arthritis Res Ther. 2007;9(1):202
pubmed: 17306038
Curr Protoc Immunol. 2001 May;Chapter 1:Unit 1.10
pubmed: 18432668
Br J Rheumatol. 1992 Sep;31(9):583-91
pubmed: 1381980
Ann Rheum Dis. 2015 Mar;74(3):e13
pubmed: 24532676
Nat Rev Rheumatol. 2018 Mar;14(3):157-169
pubmed: 29416134
Arthritis Rheumatol. 2018 Feb;70(2):193-203
pubmed: 29045049
Eur J Immunol. 2013 Nov;43(11):2797-809
pubmed: 24258910
J Exp Med. 2006 Apr 17;203(4):1045-54
pubmed: 16567390
J Immunol. 2015 Mar 15;194(6):2539-50
pubmed: 25672758
PLoS One. 2016 May 26;11(5):e0155936
pubmed: 27227821
Arthritis Res Ther. 2005;7(5):R1148-57
pubmed: 16207332
J Immunol. 2001 Feb 15;166(4):2460-8
pubmed: 11160306
Ann Rheum Dis. 2008 Nov;67(11):1603-9
pubmed: 18203760
Immunity. 2014 Feb 20;40(2):289-302
pubmed: 24530057