Molecular diagnosis of the central nervous system (CNS) infections.
Diagnóstico molecular
Encefalitis
Encephalitis
Meningitis
Molecular diagnosis
Paneles sindrómicos
Syndromic panels
Journal
Enfermedades infecciosas y microbiologia clinica (English ed.)
ISSN: 2529-993X
Titre abrégé: Enferm Infecc Microbiol Clin (Engl Ed)
Pays: Spain
ID NLM: 101777541
Informations de publication
Date de publication:
25 Apr 2020
25 Apr 2020
Historique:
received:
07
01
2020
revised:
27
02
2020
accepted:
09
03
2020
entrez:
30
4
2020
pubmed:
30
4
2020
medline:
30
4
2020
Statut:
aheadofprint
Résumé
Central nervous system (CNS) infections such as meningitis and encephalitis are medical emergencies that require rapid diagnosis of the causative pathogen to guide early and adequate treatment since a delay in implementing an adequate antimicrobial therapy can lead to death. The current microbiological diagnostic methods based on culture or antigen detection have important limitations in their capacity to accurately identify the different potential pathogens causing CNS and, in the time, to obtaining results. Rapid syndromic molecular arrays have been developed. The main advantage of using a meningoencephalitis panel based in a multiplex test is that includes bacteria, viruses and fungi, covering the most prevalent microorganisms causing meningitis and encephalitis and the turn-around time is circa 1h. The use of these multiplex-PCR based tools is reviewed and the advantages and disadvantages of this technique are discussed.
Identifiants
pubmed: 32345489
pii: S0213-005X(20)30168-3
doi: 10.1016/j.eimc.2020.03.001
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
spa
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020. Publicado por Elsevier España, S.L.U.