Novel immunological approach to asses donor reactivity of transplant recipients using a humanized mouse model.
Adolescent
Adult
Aged
Animals
Child
Child, Preschool
Disease Models, Animal
Female
Graft Rejection
/ immunology
Healthy Volunteers
Heterografts
/ immunology
Humans
Infant
Interleukin Receptor Common gamma Subunit
/ genetics
Liver Transplantation
Living Donors
Male
Mice
Mice, Inbred NOD
Mice, SCID
Middle Aged
T-Lymphocytes
/ immunology
Transplant Recipients
Young Adult
Alloreactivity
Humanized mouse
Liver transplantation
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
17
12
2019
revised:
04
04
2020
accepted:
22
04
2020
pubmed:
30
4
2020
medline:
9
3
2021
entrez:
30
4
2020
Statut:
ppublish
Résumé
In organ transplantation, a reproducible and robust immune-monitoring assay has not been established to determine individually tailored immunosuppressants (IS). We applied humanized mice reconstituted with human (hu-) peripheral blood mononuclear cells (PBMCs) obtained from living donor liver transplant recipients to evaluate their immune status. Engraftment of 2.5 × 10
Identifiants
pubmed: 32345498
pii: S0198-8859(19)31452-1
doi: 10.1016/j.humimm.2020.04.007
pii:
doi:
Substances chimiques
Interleukin Receptor Common gamma Subunit
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
342-353Informations de copyright
Copyright © 2020 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.