Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.

Aged Cohort Studies Early Detection of Cancer / methods Female Hematologic Tests Humans Mass Screening / methods Neoplasms / blood Positron Emission Tomography Computed Tomography

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
03 07 2020
Historique:
received: 30 03 2020
accepted: 23 04 2020
pubmed: 30 4 2020
medline: 18 7 2020
entrez: 30 4 2020
Statut: ppublish

Résumé

Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomography-computed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. One percent of participants underwent PET-CT imaging based on false-positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multicancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.

Identifiants

DOI: 10.1126/science.abb9601 PMID: 32345712 PMC: PMC7509949
pubmed: 32345712
pii: science.abb9601
doi: 10.1126/science.abb9601
pmc: PMC7509949
mid: NIHMS1599179
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : U01 CA152753
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS113016
Pays : United States
Organisme : NCI NIH HHS
ID : HHSN261201600034C
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA228991
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA230691
Pays : United States
Organisme : NCI NIH HHS
ID : R44 CA203350
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA230400
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007309
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM136577
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA062924
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2020, American Association for the Advancement of Science.

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Auteurs

Anne Marie Lennon (AM)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
Department of Medicine Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
ORCID: 0000-0001-8957-3945

Adam H Buchanan (AH)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
ORCID: 0000-0002-6518-2453

Isaac Kinde (I)

Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.

Andrew Warren (A)

Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
Third Rock Ventures, LLC, 29 Newbury Street Boston, MA 02116, USA.
ORCID: 0000-0003-1948-0289

Ashley Honushefsky (A)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
ORCID: 0000-0002-8389-0218

Ariella T Cohain (AT)

Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
ORCID: 0000-0003-2375-0683

David H Ledbetter (DH)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
ORCID: 0000-0001-8934-4210

Fred Sanfilippo (F)

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 100 Woodruff Circle Atlanta, GA 30322, USA.
ORCID: 0000-0001-5302-0521

Kathleen Sheridan (K)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.

Dillenia Rosica (D)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
ORCID: 0000-0002-8405-2857

Christian S Adonizio (CS)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
Geisinger Cancer Institute, 100 N. Academy Avenue Danville, PA 17822, USA.

Hee Jung Hwang (HJ)

Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
ORCID: 0000-0002-0337-2323

Kamel Lahouel (K)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.

Joshua D Cohen (JD)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
ORCID: 0000-0003-1158-5668

Christopher Douville (C)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
ORCID: 0000-0002-2510-4151

Aalpen A Patel (AA)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
ORCID: 0000-0001-7554-3286

Leonardo N Hagmann (LN)

Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.

David D Rolston (DD)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
ORCID: 0000-0002-8707-949X

Nirav Malani (N)

Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
ORCID: 0000-0002-4218-0551

Shibin Zhou (S)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
ORCID: 0000-0003-1941-4425

Chetan Bettegowda (C)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
Department of Neurosurgery, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.

David L Diehl (DL)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.

Bobbi Urban (B)

Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
ORCID: 0000-0003-2516-3730

Christopher D Still (CD)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
ORCID: 0000-0001-8006-8483

Lisa Kann (L)

Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
ORCID: 0000-0002-3350-0963

Julie I Woods (JI)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.

Zachary M Salvati (ZM)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.

Joseph Vadakara (J)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
ORCID: 0000-0002-5796-0737

Rosemary Leeming (R)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
ORCID: 0000-0001-9492-5407

Prianka Bhattacharya (P)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.

Carroll Walter (C)

Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
ORCID: 0000-0003-2532-0564

Alex Parker (A)

Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
ORCID: 0000-0003-1278-6680

Christoph Lengauer (C)

Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
Third Rock Ventures, LLC, 29 Newbury Street Boston, MA 02116, USA.

Alison Klein (A)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
Department of Epidemiology, the Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street Baltimore, MD 21205, USA.
ORCID: 0000-0003-2737-8399

Cristian Tomasetti (C)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
Department of Biostatistics, the Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street Baltimore, MD 21205, USA.
ORCID: 0000-0003-3277-4804

Elliot K Fishman (EK)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
Department of Radiology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD, 21205, USA.
ORCID: 0000-0002-2567-1658

Ralph H Hruban (RH)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
Department of Pathology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
ORCID: 0000-0003-4554-5672

Kenneth W Kinzler (KW)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA. npapado1@jhmi.edu vogelbe@jhmi.edu kinzlke@jhmi.edu.
The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
ORCID: 0000-0001-5591-1176

Bert Vogelstein (B)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA. npapado1@jhmi.edu vogelbe@jhmi.edu kinzlke@jhmi.edu.
The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
ORCID: 0000-0003-0766-3854

Nickolas Papadopoulos (N)

Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA. npapado1@jhmi.edu vogelbe@jhmi.edu kinzlke@jhmi.edu.
The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
Department of Pathology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
ORCID: 0000-0001-7135-7451

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Feasibility of blood testing combined with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Feasibility of blood testing combined with...
questionsmedicales.fr › Diagnostic › Diagnostic précoce › Dépistage précoce du cancer › Feasibility of blood testing combined with...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Tests hématologiques › Feasibility of blood testing combined with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Feasibility of blood testing combined with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Dépistage de masse › Feasibility of blood testing combined with...
questionsmedicales.fr › Tumeurs › Feasibility of blood testing combined with...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › Feasibility of blood testing combined with...