Pharmacologic PPAR-γ Activation Reprograms Bone Marrow Macrophages and Partially Rescues HSPC Mobilization in Human and Murine Diabetes.
Adipogenesis
Animals
Bone Marrow Cells
/ drug effects
Cellular Reprogramming
Chemokine CXCL12
/ biosynthesis
Diabetes Mellitus, Experimental
/ drug therapy
Female
Hematopoietic Stem Cell Mobilization
Humans
Macrophages
/ drug effects
Male
Mice
Mice, Inbred C57BL
Oncostatin M
/ antagonists & inhibitors
PPAR gamma
/ agonists
Pioglitazone
/ pharmacology
Src Homology 2 Domain-Containing, Transforming Protein 1
/ physiology
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
27
06
2019
accepted:
22
04
2020
pubmed:
30
4
2020
medline:
31
12
2020
entrez:
30
4
2020
Statut:
ppublish
Résumé
Mobilization of hematopoietic stem/progenitor cells (HSPC) from the bone marrow (BM) is impaired in diabetes. Excess oncostatin M (OSM) produced by M1 macrophages in the diabetic BM signals through p66Shc to induce
Identifiants
pubmed: 32345753
pii: db19-0640
doi: 10.2337/db19-0640
doi:
Substances chimiques
Chemokine CXCL12
0
PPAR gamma
0
Shc1 protein, mouse
0
Src Homology 2 Domain-Containing, Transforming Protein 1
0
Oncostatin M
106956-32-5
Pioglitazone
X4OV71U42S
Banques de données
figshare
['10.2337/figshare.12179910']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1562-1572Informations de copyright
© 2020 by the American Diabetes Association.