Modulatory effect of Tim-3/Galectin-9 axis on T-cell-mediated immunity in pulmonary tuberculosis.
Adult
Cytokines
/ metabolism
Female
Galectins
/ metabolism
Gene Expression Regulation
/ immunology
Hepatitis A Virus Cellular Receptor 2
/ metabolism
Humans
Immunity, Cellular
Leukocytes, Mononuclear
/ immunology
Lymphocyte Activation
/ immunology
Macrophages
/ immunology
Male
Middle Aged
Mycobacterium tuberculosis
/ physiology
T-Lymphocytes, Regulatory
/ immunology
Th1 Cells
/ immunology
Tuberculosis, Pulmonary
/ genetics
Journal
Journal of biosciences
ISSN: 0973-7138
Titre abrégé: J Biosci
Pays: India
ID NLM: 8100809
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
30
4
2020
pubmed:
30
4
2020
medline:
14
1
2021
Statut:
ppublish
Résumé
Patients affected by pulmonary tuberculosis (PTB) manifest deficiencies in innate cellular immunity. The Tim3/Galectin-9 axis is an important regulator of Th1 cell immunity, leading to Th1 cell apoptosis. Herein, this study aims to clarify the underlying roles of the Tim-3/Galectin-9 axis in T-cell immunity in PTB. Peripheral blood mononuclear cells (PBMCs) were extracted from subjects with and without PTB to examine the expression of CD4, CD8, CD25, and Tim-3 under the stimulation of
Substances chimiques
Cytokines
0
Galectins
0
HAVCR2 protein, human
0
Hepatitis A Virus Cellular Receptor 2
0
LGALS9 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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