Transport and deposition of hygroscopic particles in asthmatic subjects with and without airway narrowing.
Airway constriction
Cluster analysis
Computational fluid dynamics
Hygroscopic growth
Particle deposition
Journal
Journal of aerosol science
ISSN: 0021-8502
Titre abrégé: J Aerosol Sci
Pays: England
ID NLM: 1263115
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
26
09
2019
revised:
21
04
2020
accepted:
24
04
2020
pubmed:
30
4
2020
medline:
30
4
2020
entrez:
30
4
2020
Statut:
ppublish
Résumé
This study numerically investigates the effect of hygroscopicity on transport and deposition of particles in severe asthmatic lungs with distinct airway structures. The study human subjects were selected from two imaging-based severe asthmatic clusters with one characterized by non-constricted airways and the other by constricted airways in the lower left lobe (LLL). We compared the deposition fractions of sodium chloride (NaCl) particles with a range of aerodynamic diameters (1-8 μm) in cluster archetypes under conditions with and without hygroscopic growth. The temperature and water vapor distributions in the airways were simulated with an airway wall boundary condition that accounts for variable temperature and water vapor evaporation at the interface between the lumen and the airway surface liquid layer. On average, the deposition fraction increased by about 6% due to hygroscopic particle growth in the cluster subjects with constricted airways, while it increased by only about 0.5% in those with non-constricted airways. The effect of particle growth was most significant for particles with an initial diameter of
Identifiants
pubmed: 32346183
doi: 10.1016/j.jaerosci.2020.105581
pii: S0021-8502(20)30070-7
pii: 105581
pmc: PMC7187883
doi:
Types de publication
Journal Article
Langues
eng
Pagination
105581Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES005605
Pays : United States
Organisme : NIOSH CDC HHS
ID : T42 OH008491
Pays : United States
Organisme : FDA HHS
ID : U01 FD005837
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL114494
Pays : United States
Informations de copyright
© 2020 Published by Elsevier Ltd.
Références
Ann Biomed Eng. 2015 Nov;43(11):2708-21
pubmed: 25869455
Aerosol Sci Technol. 2011 Jan 1;45(7):884-899
pubmed: 21804683
J Aerosol Med Pulm Drug Deliv. 2019 Aug;32(4):213-223
pubmed: 30888242
Pharm Res. 2010 Sep;27(9):1800-11
pubmed: 20454837
Aerosol Sci Technol. 2011 Jan;45(1):11-25
pubmed: 21307962
Ann Biomed Eng. 2000 Jul;28(7):793-802
pubmed: 11016416
Ther Deliv. 2017 Dec;8(12):1051-1061
pubmed: 29125064
J Pharm Sci. 2016 Jan;105(1):147-59
pubmed: 26852850
Ann Biomed Eng. 2014 Oct;42(10):2117-31
pubmed: 25081386
Respir Physiol Neurobiol. 2007 Aug 1;157(2-3):295-309
pubmed: 17360247
Int J Pharm. 2000 Jan 5;193(2):227-30
pubmed: 10606786
Inhal Toxicol. 2014 Feb;26(3):193-206
pubmed: 24517842
J Aerosol Med. 2006 Summer;19(2):184-98
pubmed: 16796543
Bull Math Biol. 1982;44(3):425-42
pubmed: 7104512
Comput Fluids. 2017 Apr 22;148:1-9
pubmed: 28959080
J Allergy Clin Immunol. 2017 Sep;140(3):690-700.e8
pubmed: 28143694
Proc Am Thorac Soc. 2004;1(4):321-8
pubmed: 16113453
Biomech Model Mechanobiol. 2017 Apr;16(2):583-596
pubmed: 27704229
Aerosol Sci Technol. 2010 Jun 1;44(6):473-483
pubmed: 20640054
J Appl Physiol (1985). 2019 Jul 1;127(1):122-133
pubmed: 31095459
J Biomech. 2010 Aug 10;43(11):2159-63
pubmed: 20483412
Pharm Res. 2012 Jun;29(6):1670-88
pubmed: 22290350