B7-H3-Targeted CAR-T Cells Exhibit Potent Antitumor Effects on Hematologic and Solid Tumors.
B7-H3
CAR-T
acute myeloid leukemia
chimeric antigen receptor
melanoma
Journal
Molecular therapy oncolytics
ISSN: 2372-7705
Titre abrégé: Mol Ther Oncolytics
Pays: United States
ID NLM: 101666776
Informations de publication
Date de publication:
26 Jun 2020
26 Jun 2020
Historique:
received:
05
03
2020
accepted:
27
03
2020
entrez:
30
4
2020
pubmed:
30
4
2020
medline:
30
4
2020
Statut:
epublish
Résumé
Recently, B7-H3 was frequently reported to be overexpressed in various cancer types and has been suggested to be a promising target for cancer immunotherapy. In the present study, we analyzed the mRNA expression of B7-H3 in The Cancer Genome Atlas (TCGA) database and validated its expression across multiple cancer types. We then generated a novel B7-H3-targeted chimeric antigen receptor (CAR) and tested its antitumor activity both
Identifiants
pubmed: 32346608
doi: 10.1016/j.omto.2020.03.019
pii: S2372-7705(20)30044-9
pmc: PMC7178328
doi:
Types de publication
Journal Article
Langues
eng
Pagination
180-189Informations de copyright
© 2020 The Author(s).
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