X-Irradiation at 0.5 Gy after the forced swim test reduces forced swimming-induced immobility in mice.
X-irradiation
antioxidants
brain
forced swim test
oxidative stress
Journal
Journal of radiation research
ISSN: 1349-9157
Titre abrégé: J Radiat Res
Pays: England
ID NLM: 0376611
Informations de publication
Date de publication:
06 Jul 2020
06 Jul 2020
Historique:
received:
08
12
2019
revised:
01
01
2020
accepted:
22
03
2020
pubmed:
30
4
2020
medline:
9
7
2021
entrez:
30
4
2020
Statut:
ppublish
Résumé
The forced swim test (FST) is a screening model for antidepressant activity; it causes immobility and induces oxidative stress. We previously reported that radon inhalation has antidepressant-like effects in mice potentially through the activation of antioxidative functions upon radon inhalation. This study aimed to investigate the effect of prior and post low-dose X-irradiation (0.1, 0.5, 1.0 and 2.0 Gy) on FST-induced immobility and oxidative stress in the mouse brain, and the differences, if any, between the two. Mice received X-irradiation before or after the FST repeatedly for 5 days. In the post-FST-irradiated group, an additional FST was conducted 4 h after the last irradiation. Consequently, animals receiving prior X-irradiation (0.1 Gy) had better mobility outcomes than sham-irradiated mice; however, their levels of lipid peroxide (LPO), an oxidative stress marker, remained unchanged. However, animals that received post-FST X-irradiation (0.5 Gy) had better mobility outcomes and their LPO levels were significantly lower than those of the sham-irradiated mice. The present results indicate that 0.5 Gy X-irradiation after FST inhibits FST-induced immobility and oxidative stress in mice.
Identifiants
pubmed: 32346734
pii: 5826468
doi: 10.1093/jrr/rraa022
pmc: PMC7336566
doi:
Substances chimiques
Antioxidants
0
Lipid Peroxides
0
Superoxide Dismutase
EC 1.15.1.1
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
517-523Informations de copyright
© Crown copyright 2020.
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