The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond.
CD36 Antigens
/ blood
Ceramides
/ adverse effects
Diabetes Mellitus, Type 2
/ metabolism
Fatty Acids, Nonesterified
/ metabolism
Female
Glucose
/ metabolism
Humans
Hyperglycemia
/ complications
Inflammation
/ metabolism
Insulin Secretion
/ physiology
Insulin-Secreting Cells
/ metabolism
Lipids
/ toxicity
Male
Metabolic Syndrome
/ metabolism
Oxidative Stress
/ physiology
Reactive Oxygen Species
/ metabolism
Signal Transduction
CD36 antigens
Ceramides
Diabetes mellitus, type 2
Fatty acids
Hyperglycemia
Inflammation
Insulin-secreting cells
Oxidative stress
Reactive oxygen species
Journal
Diabetes & metabolism journal
ISSN: 2233-6087
Titre abrégé: Diabetes Metab J
Pays: Korea (South)
ID NLM: 101556588
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
06
03
2020
accepted:
25
03
2020
entrez:
30
4
2020
pubmed:
30
4
2020
medline:
9
6
2021
Statut:
ppublish
Résumé
Impaired β-cell function is the key pathophysiology of type 2 diabetes mellitus, and chronic exposure of nutrient excess could lead to this tragedy. For preserving β-cell function, it is essential to understand the cause and mechanisms about the progression of β-cells failure. Glucotoxicity, lipotoxicity, and glucolipotoxicity have been suggested to be a major cause of β-cell dysfunction for decades, but not yet fully understood. Fatty acid translocase cluster determinant 36 (CD36), which is part of the free fatty acid (FFA) transporter system, has been identified in several tissues such as muscle, liver, and insulin-producing cells. Several studies have reported that induction of CD36 increases uptake of FFA in several cells, suggesting the functional interplay between glucose and FFA in terms of insulin secretion and oxidative metabolism. However, we do not currently know the regulating mechanism and physiological role of CD36 on glucolipotoxicity in pancreatic β-cells. Also, the downstream and upstream targets of CD36 related signaling have not been defined. In the present review, we will focus on the expression and function of CD36 related signaling in the pancreatic β-cells in response to hyperglycemia and hyperlipidemia (ceramide) along with the clinical studies on the association between CD36 and metabolic disorders.
Identifiants
pubmed: 32347024
pii: 44.222
doi: 10.4093/dmj.2020.0053
pmc: PMC7188969
doi:
Substances chimiques
CD36 Antigens
0
Ceramides
0
Fatty Acids, Nonesterified
0
Lipids
0
Reactive Oxygen Species
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
222-233Subventions
Organisme : YU
Pays : International
Organisme : NRF
ID : NRF-2020R1A2C1003649
Pays : International
Informations de copyright
Copyright © 2020 Korean Diabetes Association.
Déclaration de conflit d'intérêts
No potential conflict of interest relevant to this article was reported.
Références
J Diabetes Complications. 2017 Jan;31(1):21-30
pubmed: 27662780
Diabetologia. 2015 Jun;58(6):1260-71
pubmed: 25810038
Biochem Soc Trans. 2008 Oct;36(Pt 5):920-9
pubmed: 18793162
Ann N Y Acad Sci. 2001 Dec;947:350-5
pubmed: 11795289
Diabetes. 2003 Mar;52(3):726-33
pubmed: 12606514
Diabetes. 2001 Jan;50(1):69-76
pubmed: 11147797
J Diabetes Complications. 2015 Apr;29(3):400-6
pubmed: 25619588
Diabetes Metab J. 2020 Feb;44(1):134-142
pubmed: 31701685
Free Radic Biol Med. 2008 Mar 15;44(6):1001-9
pubmed: 18164270
J Clin Invest. 2010 Nov;120(11):3996-4006
pubmed: 20978343
Endocrinology. 1997 Oct;138(10):4064-8
pubmed: 9322913
Int J Clin Exp Med. 2015 Sep 15;8(9):16149-57
pubmed: 26629128
Diabetes. 2001 Feb;50 Suppl 1:S118-21
pubmed: 11272168
Arch Physiol Biochem. 2011 May;117(2):57-63
pubmed: 21250778
Redox Biol. 2017 Apr;11:126-134
pubmed: 27912197
Int J Obes (Lond). 2017 Sep;41(9):1388-1393
pubmed: 28555086
J Clin Invest. 2011 Sep;121(9):3701-12
pubmed: 21865652
Endocrinology. 2003 Jan;144(1):335-45
pubmed: 12488362
Diabetes Care. 2008 Feb;31(2):328-34
pubmed: 18000176
Diabetologia. 2007 Jun;50(6):1304-14
pubmed: 17437081
Diabetes. 1997 Nov;46(11):1733-42
pubmed: 9356019
Science. 1993 Nov 26;262(5138):1436-40
pubmed: 7504322
Diabetes. 2002 May;51(5):1437-42
pubmed: 11978640
J Biol Chem. 1994 Jul 22;269(29):18985-91
pubmed: 7518447
PLoS One. 2016 May 19;11(5):e0155611
pubmed: 27195707
Free Radic Biol Med. 2019 Apr;134:505-515
pubmed: 30735834
Endocrinology. 2002 Sep;143(9):3449-53
pubmed: 12193557
J Biol Chem. 2008 May 16;283(20):13578-85
pubmed: 18353783
Diabetes. 2001 Feb;50(2):315-21
pubmed: 11272142
Cell Metab. 2012 Aug 8;16(2):265-73
pubmed: 22883234
Cardiovasc Res. 2010 Apr 1;86(1):141-50
pubmed: 20007688
Endocrinol Metab (Seoul). 2017 Sep;32(3):375-382
pubmed: 28956368
Arch Med Sci. 2017 Aug;13(5):1031-1039
pubmed: 28883843
J Clin Med. 2019 May 18;8(5):
pubmed: 31109109
JCI Insight. 2017 Dec 21;2(24):
pubmed: 29263294
Biochim Biophys Acta. 2010 Feb;1801(2):191-7
pubmed: 19931418
Diabetes Care. 2016 Feb;39(2):179-86
pubmed: 26798148
Diabetes Technol Ther. 2013 Aug;15(8):680-7
pubmed: 23844572
J Biol Chem. 1996 Oct 4;271(40):24776-80
pubmed: 8798748
Diabetes. 2006 Sep;55(9):2579-87
pubmed: 16936207
Diabetes. 1999 Apr;48(4):927-32
pubmed: 10102716
J Clin Endocrinol Metab. 2019 Apr 29;:
pubmed: 31034016
Diabetes. 2009 Feb;58(2):337-43
pubmed: 19008343
Nat Med. 2011 Feb;17(2):179-88
pubmed: 21217695
Gene. 2018 Jun 15;659:155-159
pubmed: 29572193
Biochim Biophys Acta. 2015 Nov;1852(11):2414-22
pubmed: 26297980
Nature. 1999 Nov 18;402(6759):309-13
pubmed: 10580504
J Cell Physiol. 2003 Jan;194(1):1-12
pubmed: 12447984
Cell Rep. 2019 Jan 2;26(1):209-221.e5
pubmed: 30605677
Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2090-7
pubmed: 21817106
Sci Rep. 2016 Feb 12;6:20930
pubmed: 26868434
Arterioscler Thromb Vasc Biol. 1996 Aug;16(8):1033-9
pubmed: 8696943
J Hepatol. 2018 Sep;69(3):705-717
pubmed: 29705240
PLoS One. 2011 Apr 11;6(4):e18417
pubmed: 21494549
Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2498-502
pubmed: 9482914
Free Radic Biol Med. 1996;20(3):463-6
pubmed: 8720919
Biochim Biophys Acta. 2010 Nov;1803(11):1298-307
pubmed: 20637247
Nat Med. 2000 Jan;6(1):41-8
pubmed: 10613822
PLoS One. 2015 Apr 13;10(4):e0121516
pubmed: 25875611
Cell Rep. 2017 Feb 28;18(9):2269-2279
pubmed: 28249170
Physiol Rev. 2010 Jan;90(1):367-417
pubmed: 20086080
Nat Immunol. 2013 Aug;14(8):812-20
pubmed: 23812099
Pediatr Surg Int. 2006 Aug;22(8):647-54
pubmed: 16838191
Cell. 2011 Sep 30;147(1):173-84
pubmed: 21962514
Cell Metab. 2006 Sep;4(3):211-21
pubmed: 16950138
J Biol Chem. 2009 Jun 12;284(24):16277-16288
pubmed: 19369259
J Clin Invest. 2006 Jul;116(7):1802-12
pubmed: 16823478
Small GTPases. 2014;5(2):9
pubmed: 25483299
Nature. 2002 Nov 21;420(6913):333-6
pubmed: 12447443
Atherosclerosis. 2018 Oct;277:163-168
pubmed: 30218892
Circulation. 2006 Sep 12;114(11):1169-76
pubmed: 16952981
Diabetologia. 2008 Jul;51(7):1226-35
pubmed: 18449527
J Clin Invest. 1997 Jul 15;100(2):290-5
pubmed: 9218505
Front Endocrinol (Lausanne). 2018 Oct 09;9:537
pubmed: 30356719
PLoS One. 2016 Sep 16;11(9):e0163046
pubmed: 27636901
Nature. 2013 Dec 5;504(7478):172-6
pubmed: 24162852
Stroke. 2008 Nov;39(11):3092-5
pubmed: 18723424
J Clin Invest. 2001 Sep;108(6):785-91
pubmed: 11560944
J Biol Chem. 1993 Aug 25;268(24):17665-8
pubmed: 7688729
Diabetologia. 2005 Jul;48(7):1401-10
pubmed: 15915335
Diabetes. 2005 Feb;54(2):472-81
pubmed: 15677505
Cell Rep. 2012 Aug 30;2(2):419-31
pubmed: 22902405
Biochem Biophys Res Commun. 2012 Apr 6;420(2):462-6
pubmed: 22430143
J Intern Med. 2012 Mar;271(3):294-304
pubmed: 21883535
Nutr Metab (Lond). 2018 Oct 23;15:76
pubmed: 30386406
Cell Rep. 2017 Sep 19;20(12):2775-2783
pubmed: 28930674
Diabetes Metab J. 2013 Apr;37(2):106-12
pubmed: 23641350
Diabetes. 2005 Dec;54 Suppl 2:S97-107
pubmed: 16306347
J Biol Chem. 2002 Dec 6;277(49):47373-9
pubmed: 12239221
Diabetes Metab J. 2019 Aug;43(4):487-494
pubmed: 31339012