Loss of excitatory amino acid transporter restraint following chronic intermittent hypoxia contributes to synaptic alterations in nucleus tractus solitarii.

Animals Astrocytes / physiology Chemoreceptor Cells / physiology Disease Models, Animal Excitatory Postsynaptic Potentials / physiology Glutamate Plasma Membrane Transport Proteins / antagonists & inhibitors Glutamic Acid / metabolism Hypoxia / metabolism Male Rats Rats, Sprague-Dawley Signal Transduction / physiology Sleep Apnea, Obstructive / metabolism Solitary Nucleus / metabolism
astrocytes chemoreflex glutamate signaling

Journal

Journal of neurophysiology
ISSN: 1522-1598
Titre abrégé: J Neurophysiol
Pays: United States
ID NLM: 0375404

Informations de publication

Date de publication:
01 06 2020
Historique:
pubmed: 30 4 2020
medline: 20 7 2021
entrez: 30 4 2020
Statut: ppublish

Résumé

Peripheral viscerosensory afferent signals are transmitted to the nucleus tractus solitarii (nTS) via release of glutamate. Following release, glutamate is removed from the extrasynaptic and synaptic cleft via excitatory amino acid transporters (EAATs), thus limiting glutamate receptor activation or over activation, and maintaining its working range. We have shown that EAAT block with the antagonist

Identifiants

DOI: 10.1152/jn.00766.2019 PMID: 32347148 PMC: PMC7311725
pubmed: 32347148
doi: 10.1152/jn.00766.2019
pmc: PMC7311725
doi:

Substances chimiques

Glutamate Plasma Membrane Transport Proteins 0
Glutamic Acid 3KX376GY7L

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2122-2135

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK108765
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS060664
Pays : United States
Organisme : HHS | National Institutes of Health (NIH)
ID : DK108765
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL128454
Pays : United States
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI)
ID : HL128454
Pays : International

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Auteurs

Diana Martinez (D)

Department of Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri.
ORCID: 0000-0003-0982-4092

Richard C Rogers (RC)

Pennington Biomedical Research Center, Baton Rouge, Louisiana.
ORCID: 0000-0002-4476-9052

Eileen M Hasser (EM)

Department of Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri.
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri.
ORCID: 0000-0003-4552-1021

Gerlinda E Hermann (GE)

Pennington Biomedical Research Center, Baton Rouge, Louisiana.
ORCID: 0000-0003-0405-2820

David D Kline (DD)

Department of Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri.
ORCID: 0000-0003-3269-0184

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Loss of excitatory amino acid transporter...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Loss of excitatory amino acid transporter...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Cellules chimioréceptrices › Loss of excitatory amino acid transporter...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Loss of excitatory amino acid transporter...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Potentiels post-synaptiques excitateurs › Loss of excitatory amino acid transporter...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Système X-AG de transport d'acides aminés › Protéines de transport transmembranaire du glutamate › Loss of excitatory amino acid transporter...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Loss of excitatory amino acid transporter...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Loss of excitatory amino acid transporter...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Loss of excitatory amino acid transporter...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Loss of excitatory amino acid transporter...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Loss of excitatory amino acid transporter...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Syndrome d'apnées obstructives du sommeil › Loss of excitatory amino acid transporter...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Rhombencéphale › Myélencéphale › Moelle allongée › Noyau du tractus solitaire › Loss of excitatory amino acid transporter...