Splice-dependent trans-synaptic PTPδ-IL1RAPL1 interaction regulates synapse formation and non-REM sleep.
alternative splicing
receptor tyrosine phosphatase
sleep behavior and rhythm
synapse development
synaptic adhesion
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
02 06 2020
02 06 2020
Historique:
received:
30
11
2019
revised:
17
03
2020
accepted:
23
03
2020
pubmed:
30
4
2020
medline:
7
4
2021
entrez:
30
4
2020
Statut:
ppublish
Résumé
Alternative splicing regulates trans-synaptic adhesions and synapse development, but supporting in vivo evidence is limited. PTPδ, a receptor tyrosine phosphatase adhering to multiple synaptic adhesion molecules, is associated with various neuropsychiatric disorders; however, its in vivo functions remain unclear. Here, we show that PTPδ is mainly present at excitatory presynaptic sites by endogenous PTPδ tagging. Global PTPδ deletion in mice leads to input-specific decreases in excitatory synapse development and strength. This involves tyrosine dephosphorylation and synaptic loss of IL1RAPL1, a postsynaptic partner of PTPδ requiring the PTPδ-meA splice insert for binding. Importantly, PTPδ-mutant mice lacking the PTPδ-meA insert, and thus lacking the PTPδ interaction with IL1RAPL1 but not other postsynaptic partners, recapitulate biochemical and synaptic phenotypes of global PTPδ-mutant mice. Behaviorally, both global and meA-specific PTPδ-mutant mice display abnormal sleep behavior and non-REM rhythms. Therefore, alternative splicing in PTPδ regulates excitatory synapse development and sleep by modulating a specific trans-synaptic adhesion.
Identifiants
pubmed: 32347567
doi: 10.15252/embj.2019104150
pmc: PMC7265247
doi:
Substances chimiques
Interleukin-1 Receptor Accessory Protein
0
interleukin-1 receptor accessory protein-like 1, mouse
0
Protein Tyrosine Phosphatases
EC 3.1.3.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e104150Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2017R1A5A2015391
Organisme : Institute for Basic Science
ID : IBS-R002-D1
Informations de copyright
© 2020 The Authors. Published under the terms of the CC BY 4.0 license.
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