Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor.
Journal
ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906
Informations de publication
Date de publication:
19 06 2020
19 06 2020
Historique:
pubmed:
30
4
2020
medline:
13
4
2021
entrez:
30
4
2020
Statut:
ppublish
Résumé
Glucagon-like peptide 1 (GLP-1) is a natural peptide agonist of the GLP-1 receptor (GLP-1R) found on pancreatic β-cells. Engagement of the receptor stimulates insulin release in a glucose-dependent fashion and increases β-cell mass, two ideal features for pharmacologic management of type 2 diabetes. Thus, intensive efforts have focused on developing GLP-1-based peptide agonists of GLP-1R for therapeutic application. A primary challenge has been the naturally short half-life of GLP-1 due to its rapid proteolytic degradation
Identifiants
pubmed: 32348108
doi: 10.1021/acschembio.0c00308
pmc: PMC7366314
mid: NIHMS1591291
doi:
Substances chimiques
Glucagon-Like Peptide-1 Receptor
0
Peptides
0
Glucagon-Like Peptide 1
89750-14-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1340-1348Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK078081
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197583
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211399
Pays : United States
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