Task phase-specific involvement of the rat posterior parietal cortex in performance of the TUNL task.
delay
electrical stimulation
nonmatch-to-sample
operant conditioning
pattern separation
reward
temporary inactivation
touchscreen
visuospatial
working memory
Journal
Genes, brain, and behavior
ISSN: 1601-183X
Titre abrégé: Genes Brain Behav
Pays: England
ID NLM: 101129617
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
26
11
2019
revised:
23
04
2020
accepted:
23
04
2020
pubmed:
30
4
2020
medline:
4
1
2022
entrez:
30
4
2020
Statut:
ppublish
Résumé
The posterior parietal cortex (PPC) participates in cognitive processes including working memory (WM), sensory evidence accumulation, and perceptually guided decision making. However, surprisingly little work has used temporally precise manipulations to dissect its role in different epochs of behavior taking place over short timespans, such as WM tasks. As a result, a consistent view of the temporally precise role of the PPC in these processes has not been described. In the present study, we investigated the temporally specific role of the PPC in the Trial-Unique, Nonmatching-to-Location (TUNL) task, a touchscreen-based, visuospatial WM task that relies on the PPC. To disrupt PPC activity in a temporally precise manner, we applied mild intracranial electrical stimulation (ICES). We found that intra-PPC ICES (100 μA) significantly impaired accuracy in TUNL without significantly altering response latency. Moreover, we found that the impairment was specific to ICES applied during the delay and test phases of TUNL. Consistent with previous reports showing delay- and choice-specific neuronal activity in the PPC, the results provide evidence that the rat PPC is required for maintaining memory representations of stimuli over a delay period as well as for making successful comparisons and choices between test stimuli. In contrast, the PPC appears not to be critical for initial encoding of sample stimuli. This pattern of results may indicate that early encoding of visual stimuli is independent of the PPC or that the PPC becomes engaged only when visual stimuli are spatially complex or involve memory or decision making.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12659Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2020 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.
Références
Brigadoi S, Cutini S, Meconi F, et al. On the role of the inferior intraparietal sulcus in visual working memory for lateralized single-feature objects. J Cogn Neurosci. 2017;29:337-351.
Champod AS, Petrides M. Dissociable roles of the posterior parietal and the prefrontal cortex in manipulation and monitoring processes. Proc Natl Acad Sci. 2007;104:14837-14842.
McDaniel WF, Compton DM, Smith SR. Spatial learning following posterior parietal or hippocampal lesions. Neuroreport. 1994;5:1713-1717.
Scott GA, Roebuck AJ, Greba Q, Howland JG. Performance of the trial-unique, delayed non-matching-to-location (TUNL) task depends on AMPA/Kainate, but not NMDA, ionotropic glutamate receptors in the rat posterior parietal cortex. Neurobiol Learn Mem. 2019;159:16-23.
Katz LN, Yates JL, Pillow JW, Huk AC. Dissociated functional significance of decision-related activity in the primate dorsal stream. Nature. 2016;535:285-288.
Mackey WE, Devinsky O, Doyle WK, Golfinos JG, Curtis CE. Human parietal cortex lesions impact the precision of spatial working memory. J Neurophysiol. 2016;116:1049-1054.
Curtis CE. Prefrontal and parietal contributions to spatial working memory. Neuroscience. 2006;139:173-180.
Öztekin I, Mcelree B, Staresina BP, Davachi L. Working memory retrieval: Contributions of the left prefrontal cortex, the left parietal cortex, and the hippocampus. J Cogn Neurosci. 2016;21:581-593.
Ravizza SM, Delgado MR, Chein JM, Becker JT, Fiez JA. Functional dissociations within the inferior parietal cortex in verbal working memory. Neuroimage. 2004;22:562-573.
van Asselen M, Kessels RPC, Neggers SFW, Kappelle LJ, Frijns CJM, Postma A. Brain areas involved in spatial working memory. Neuropsychologia. 2006;44:1185-1194.
Vogel EK, Machizawa MG. Neural activity predicts individual differences in visual working memory capacity. Nature. 2004;428:748-751.
Espina-Marchant P, Pinto-Hamuy T, Bustamante D, Morales P, Robles L, Herrera-marschitz M. Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks. Biol Res. 2006;39:601-609.
Licata AM, Kaufman MT, Raposo D, Ryan MB, Sheppard JP, Churchland AK. Posterior parietal cortex guides visual decisions in rats. J Neurosci. 2017;37:4954-4966.
Harvey CD, Coen P, Tank DW. Choice-specific sequences in parietal cortex during a virtual- navigation decision task. Nature. 2012;484:62-68.
Scott BB, Constantinople CM, Akrami A, Hanks TD, Brody CD, Tank DW. Fronto-parietal cortical circuits encode accumulated evidence with a diversity of timescales. Neuron. 2017;95:385-398.
Wörtwein G, Mogensen J, Divac I. Retention and relearning of spatial delayed alternation in rats after ablation of the prefrontal or total non-prefrontal isocortex. Behav Brain Res. 1994;63:127-131.
Kolb B, Buhrmann K, McDonald R, Sutherland RJ. Dissociation of the medial prefrontal, posterior parietal, and posterior temporal cortex for spatial navigation and recognition memory in the rat. Cereb Cortex. 1994;4:664-680.
Scott GA, Zabder NK, Greba Q, Howland JG. Performance of the odour span task is not impaired following inactivations of parietal cortex in rats. Behav Brain Res. 2018;341:181-188.
Erlich JC, Brunton BW, Duan CA, Hanks TD, Brody CD. Distinct effects of prefrontal and parietal cortex inactivations on an accumulation of evidence task in the rat. Elife. 2015;4:1-28.
Pisupati S, Chartarifsky L, Churchland AK. Decision activity in parietal cortex - leader or follower? Trends Cogn Sci. 2016;20:788-789.
Goard MJ, Pho GN, Woodson J, Sur M. Distinct roles of visual, parietal, and frontal motor cortices in memory-guided sensorimotor decisions. Elife. 2016;5:1-30.
Akrami A, Kopec CD, Diamond ME, Brody CD. Posterior parietal cortex represents sensory history and mediates its effects on behaviour. Nature. 2018;554:368-372.
Dudchenko PA, Talpos JC, Young JW, Baxter MG. Animal models of working memory: A review of tasks that might be used in screening drug treatments for the memory impairments found in schizophrenia. Neurosci Biobehav Rev. 2013;37:2111-2124.
Hvoslef-Eide M, Mar AC, Nilsson SRO, et al. The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia. Psychopharmacology (Berl). 2015;232:3853-3872.
Oomen CA, Hvoslef-Eide M, Heath CJ, et al. The touchscreen operant platform for testing working memory and pattern separation in rats and mice. Nat Protoc. 2013;8:2006-2021.
Davies DA, Hurtubise JL, Greba Q, Howland JG. Medial prefrontal cortex and dorsomedial striatum are necessary for the trial-unique, delayed nonmatching-to-location (TUNL) task in rats: Role of NMDA receptors. Learn Mem. 2017;24:262-267.
Hurtubise JL, Marks WN, Davies DA, Catton JK, Baker GB, Howland JG. MK-801-induced impairments on the trial-unique, delayed nonmatching-to-location task in rats: effects of acute sodium nitroprusside. Psychopharmacology (Berl). 2017;234:211-222.
Roebuck AJ, Liu MC, Lins BR, Scott GA, Howland JG. Acute stress, but not corticosterone, facilitates acquisition of paired associates learning in rats using touchscreen-equipped operant conditioning chambers. Behav Brain Res. 2018;348:139-149.
Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 6th ed.Cambridge, MA: Academic Press; 2006.
Rodgers CC, & DeWeese MR. (2014) Neural correlates of task switching in prefrontal cortex and primary auditory cortex in a novel stimulus selection task for rodents. Neuron 82, 1157-1170.
Flynn C, Teskey GC. Reduction of seizure thresholds following electrical stimulation of sensorimotor cortex is dependent on stimulation intensity and is not related to synaptic potentiation. Neuroscience. 2007;149:263-272.
Kolb B, Sutherland RJ, Whishaw IQ. A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats. Behav Neurosci. 1983;97:13-27.
Supèr H, Spekreijse H, Lamme VAF. A neural correlate of working memory in the monkey primary visual cortex. Science. 2001;293:120-124.
Pidgeon LM, Morcom AM. Cortical pattern separation and item-specific memory encoding. Neuropsychologia. 2016;85:256-271.
Stehberg J, Levy D, Zangen A. Impairment of aversive memory reconsolidation by localized intracranial electrical stimulation. Eur J Neurosci. 2009;29:964-969.