Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View.
MDR
NF-κB
cancer
drug target
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Apr 2020
27 Apr 2020
Historique:
received:
08
04
2020
revised:
24
04
2020
accepted:
25
04
2020
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
2
2
2021
Statut:
epublish
Résumé
Multidrug resistance (MDR), of the innate and acquired types, is one of major problems in treating tumor diseases with a good chance of success. In this review, we examine the key role of nuclear factor-kappa B (NF-κB) to induce MDR in three tumor models characterized precisely by innate or acquired MDR, in particular triple negative breast cancer (TNBC), hepatocellular carcinoma (HCC), and acute myeloid leukemia (AML). We also present different pharmacological approaches that our group have employed to reduce the expression/activation of this transcriptional factor and thus to restore chemo-sensitivity. Finally, we examine the latest scientific evidence found by other groups, the most significant clinical trials regarding NF-κB, and new perspectives on the possibility to consider this transcriptional factor a valid drug target in neoplastic diseases.
Identifiants
pubmed: 32349210
pii: ijms21093070
doi: 10.3390/ijms21093070
pmc: PMC7246796
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Biomarkers, Tumor
0
NF-kappa B
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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