Multimodal Targeted Deep Sequencing of Circulating Tumor Cells and Matched Cell-Free DNA Provides a More Comprehensive Tool to Identify Therapeutic Targets in Metastatic Breast Cancer Patients.
cell-free DNA
circulating tumor DNA
circulating tumor cells
liquid biopsy
metastatic breast cancer patients
multi-parametric
multimodal
next-generation sequencing
therapy stratification
unique molecular indices
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
27 Apr 2020
27 Apr 2020
Historique:
received:
23
03
2020
revised:
17
04
2020
accepted:
22
04
2020
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
1
5
2020
Statut:
epublish
Résumé
Cell-free DNA (cfDNA) and circulating tumor cells (CTCs) exhibit great potential for therapy management in oncology. We aimed to establish a multimodal liquid biopsy strategy that is usable with minimized blood volume to deconvolute the genomic complexity of metastatic breast cancer. CTCs were isolated from 10ml blood of 18 hormone receptor-positive and human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer patients. cfDNA was isolated from plasma generated after CTC depletion and targeted sequencing analyses were conducted.
Identifiants
pubmed: 32349306
pii: cancers12051084
doi: 10.3390/cancers12051084
pmc: PMC7281124
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : QIAGEN GmbH
ID : N/A
Organisme : Graduate School of Biomedical Science Postdoctoral Excellence Programme (BIOME PEP) of the Medical Faculty University Duisburg-Essen
ID : N/A
Organisme : Open Access Publication Fund of the University of Duisburg-Essen
ID : N/A
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