CCR2 is localized in microglia and neurons, as well as infiltrating monocytes, in the lumbar spinal cord of ALS mice.
Amyotrophic lateral sclerosis
Astrocyte
CCR2
Microglia
Monocyte
Neuron
Journal
Molecular brain
ISSN: 1756-6606
Titre abrégé: Mol Brain
Pays: England
ID NLM: 101468876
Informations de publication
Date de publication:
29 04 2020
29 04 2020
Historique:
received:
21
01
2020
accepted:
22
04
2020
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
4
6
2021
Statut:
epublish
Résumé
It remains controversial whether circulating monocytes expressing CCR2 infiltrate the central nervous system (CNS) and contribute to pathogenicity of amyotrophic lateral sclerosis (ALS). A previous report used conventional immunohistochemistry to show that CCR2 is exclusively expressed by astrocytes, but not infiltrating monocytes/microglia or neurons, in the spinal cords of ALS model mice. In this study, we assessed the cellular distribution of CCR2 in the CNS of ALS mice using CCR2-reporter mice (Ccr2
Identifiants
pubmed: 32349774
doi: 10.1186/s13041-020-00607-3
pii: 10.1186/s13041-020-00607-3
pmc: PMC7191738
doi:
Substances chimiques
Ccr2 protein, mouse
0
Receptors, CCR2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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