Metabolic regulation of the lysosomal cofactor bis(monoacylglycero)phosphate in mice.
adipose tissue
body temperature
insulin
lipid metabolism
liver
lysosome
nutritional state
pancreas
phospholipids
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
04
11
2019
revised:
23
04
2020
pubmed:
1
5
2020
medline:
7
8
2021
entrez:
1
5
2020
Statut:
ppublish
Résumé
Bis(monoacylglycero)phosphate (BMP), also known as lysobisphosphatidic acid, is a phospholipid that promotes lipid sorting in late endosomes/lysosomes by activating lipid hydrolases and lipid transfer proteins. Changes in the cellular BMP content therefore reflect an altered metabolic activity of the endolysosomal system. Surprisingly, little is known about the physiological regulation of BMP. In this study, we investigated the effects of nutritional and metabolic factors on BMP profiles of whole tissues and parenchymal and nonparenchymal cells. Tissue samples were obtained from fed, fasted, 2 h refed, and insulin-treated mice, as well as from mice housed at 5°C, 22°C, or 30°C. These tissues exhibited distinct BMP profiles that were regulated by the nutritional state in a tissue-specific manner. Insulin treatment was not sufficient to mimic refeeding-induced changes in tissue BMP levels, indicating that BMP metabolism is regulated by other hormonal or nutritional factors. Tissue fractionation experiments revealed that fasting drastically elevates BMP levels in hepatocytes and pancreatic cells. Furthermore, we observed that the BMP content in brown adipose tissue strongly depends on housing temperatures. In conclusion, our observations suggest that BMP concentrations adapt to the metabolic state in a tissue- and cell-type-specific manner in mice. Drastic changes observed in hepatocytes, pancreatic cells, and brown adipocytes suggest that BMP plays a role in the functional adaption to nutrient starvation and ambient temperature.
Identifiants
pubmed: 32350080
pii: S0022-2275(20)43578-3
doi: 10.1194/jlr.RA119000516
pmc: PMC7328040
pii:
doi:
Substances chimiques
Lysophospholipids
0
Monoglycerides
0
bis(monoacylglyceryl)phosphate
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
995-1003Subventions
Organisme : Austrian Science Fund FWF
ID : P 28882
Pays : Austria
Informations de copyright
Copyright © 2020 Grabner et al. Published by The American Society for Biochemistry and Molecular Biology, Inc.
Références
Cold Spring Harb Perspect Biol. 2014 Jan 01;6(1):
pubmed: 24384568
Andrology. 2015 May;3(3):450-61
pubmed: 25951427
Traffic. 2020 Jan;21(1):76-93
pubmed: 31854087
J Lipid Res. 2019 May;60(5):1020-1031
pubmed: 30894461
Nat Commun. 2018 Aug 17;9(1):3312
pubmed: 30120233
Elife. 2019 Oct 03;8:
pubmed: 31580258
Cell. 2012 Oct 12;151(2):400-13
pubmed: 23063128
Biochim Biophys Acta. 2015 Jul;1851(7):937-45
pubmed: 25732851
J Biol Chem. 2015 Dec 11;290(50):29869-81
pubmed: 26491015
Prostaglandins Leukot Essent Fatty Acids. 2018 Sep;136:3-13
pubmed: 28314621
Ann N Y Acad Sci. 2016 May;1371(1):3-14
pubmed: 27299292
J Pathol. 2018 Dec;246(4):470-484
pubmed: 30073645
Nat Cell Biol. 2019 Jan;21(1):63-71
pubmed: 30602761
J Biol Chem. 2002 Aug 30;277(35):32157-64
pubmed: 12065580
Lipids. 2015 Sep;50(9):907-12
pubmed: 26205346
Anal Chim Acta. 2019 Nov 25;1084:60-70
pubmed: 31519235
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 1;951-952:119-28
pubmed: 24548922
J Lipid Res. 2009 Feb;50(2):243-55
pubmed: 18809971
J Biol Chem. 2006 Oct 27;281(43):32451-60
pubmed: 16905746
J Biol Chem. 1957 May;226(1):497-509
pubmed: 13428781
Nat Commun. 2017 Feb 06;8:14338
pubmed: 28165011
J Biol Chem. 2011 May 6;286(18):16332-43
pubmed: 21393243
Physiol Rev. 2004 Jan;84(1):277-359
pubmed: 14715917
J Neurochem. 2020 Jun;153(6):674-692
pubmed: 31608980
Autophagy. 2013 Aug;9(8):1131-58
pubmed: 23774882
Nature. 2010 Jan 28;463(7280):549-53
pubmed: 20111001
Toxicol Pathol. 1997 Jan-Feb;25(1):53-60
pubmed: 9061852
PLoS Comput Biol. 2017 Oct 30;13(10):e1005831
pubmed: 29084218
Angew Chem Int Ed Engl. 2012 Jan 9;51(2):533-5
pubmed: 22135237
Nat Med. 2011 Feb;17(2):200-5
pubmed: 21258337
Biochim Biophys Acta. 2009 Apr;1793(4):674-83
pubmed: 19014978
Toxicol Appl Pharmacol. 2014 Sep 15;279(3):467-476
pubmed: 24967688
EMBO Rep. 2019 Jul;20(7):e47055
pubmed: 31267706
J Lipid Res. 2007 Sep;48(9):1997-2008
pubmed: 17558022
Curr Opin Lipidol. 2018 Jun;29(3):180-185
pubmed: 29718003
Nat Rev Mol Cell Biol. 2011 Jan;12(1):21-35
pubmed: 21157483
Neurochem Res. 2011 Sep;36(9):1594-600
pubmed: 21136156
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Adv Anat Embryol Cell Biol. 2001;161:III-XIII, 1-151
pubmed: 11729749