NOD2 modulates immune tolerance via the GM-CSF-dependent generation of CD103
Acetylmuramyl-Alanyl-Isoglutamine
/ genetics
Animals
Antigens, CD
/ metabolism
Crohn Disease
Cytokines
Dendritic Cells
/ immunology
Granulocyte-Macrophage Colony-Stimulating Factor
/ metabolism
Humans
Immune Tolerance
Integrin alpha Chains
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Mutation
Nod2 Signaling Adaptor Protein
/ genetics
T-Lymphocytes, Regulatory
/ metabolism
Crohn’s disease
GM-CSF
NOD2
Tregs
dendritic cells
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
19 05 2020
19 05 2020
Historique:
pubmed:
1
5
2020
medline:
18
8
2020
entrez:
1
5
2020
Statut:
ppublish
Résumé
Four decades ago, it was identified that muramyl dipeptide (MDP), a peptidoglycan-derived bacterial cell wall component, could display immunosuppressive functions in animals through mechanisms that remain unexplored. We sought to revisit these pioneering observations because mutations in
Identifiants
pubmed: 32350141
pii: 1912866117
doi: 10.1073/pnas.1912866117
pmc: PMC7245098
doi:
Substances chimiques
Antigens, CD
0
Cytokines
0
Integrin alpha Chains
0
NOD2 protein, human
0
Nod2 Signaling Adaptor Protein
0
alpha E integrins
0
Acetylmuramyl-Alanyl-Isoglutamine
53678-77-6
Granulocyte-Macrophage Colony-Stimulating Factor
83869-56-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10946-10957Subventions
Organisme : CIHR
ID : FDN-14333
Pays : Canada
Organisme : CIHR
ID : MOP-12353
Pays : Canada
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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