[Case report of an osseous (and lymphogenic) thymic carcinoma in an adult].
Kasuistik eines ossär (und lymphogen) metastasierten Thymuskarzinoms beim Erwachsenen.
Lower back pain
Lumbar vertebrae
Palliative therapy
Spondylolisthesis
Thymoma
Journal
Der Orthopade
ISSN: 1433-0431
Titre abrégé: Orthopade
Pays: Germany
ID NLM: 0331266
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
pubmed:
1
5
2020
medline:
27
3
2021
entrez:
1
5
2020
Statut:
ppublish
Résumé
A Thymic carcinoma in adults is rare. We present the case of a 47-year-old man, who was treated conservatively for spondylolisthesis L5/S1 in our institution for several years. In the further course, the patient complained about pain exacerbation with acute lower back pain. Cross-sectional scanning showed a tumor of the lumbar vertebral body three. A biopsy of this mass revealed a metastatic thymic carcinoma of the squamous cells. After palliative therapy, the patient died 9 months after initial diagnosis. Das Thymuskarzinom des Erwachsenen ist eine seltene Diagnose. Wir präsentieren den Fall eines 47-jährigen Mannes, der bei bekannter Spondylolisthese L5/S1 in langer konservativ-orthopädischer Behandlung war. Bei im Verlauf auftretender Schmerzexazerbation der unteren Lendenwirbelsäule zeigte sich schnittbilddiagnostisch eine Raumforderung (RF) des Lendenwirbelkörpers drei. Eine Biopsie dieser RF ergab den Befund eines multipel metastasierten Thymuskarzinoms vom Plattenepithelzelltyp. Nach palliativem Therapieansatz verstarb der Mann 9 Monate nach Diagnosestellung.
Autres résumés
Type: Publisher
(ger)
Das Thymuskarzinom des Erwachsenen ist eine seltene Diagnose. Wir präsentieren den Fall eines 47-jährigen Mannes, der bei bekannter Spondylolisthese L5/S1 in langer konservativ-orthopädischer Behandlung war. Bei im Verlauf auftretender Schmerzexazerbation der unteren Lendenwirbelsäule zeigte sich schnittbilddiagnostisch eine Raumforderung (RF) des Lendenwirbelkörpers drei. Eine Biopsie dieser RF ergab den Befund eines multipel metastasierten Thymuskarzinoms vom Plattenepithelzelltyp. Nach palliativem Therapieansatz verstarb der Mann 9 Monate nach Diagnosestellung.
Identifiants
pubmed: 32350550
doi: 10.1007/s00132-020-03911-x
pii: 10.1007/s00132-020-03911-x
doi:
Types de publication
Case Reports
Journal Article
Langues
ger
Sous-ensembles de citation
IM
Pagination
326-332Références
Godersky JC, Smoker WR, Knutzon R (1987) Use of magnetic resonance imaging in the evaluation of metastatic spinal disease. Neurosurgery 21:676–680
pubmed: 3696401
Stern WE (1978) Localization and diagnosis of spinal cord tumors. Neurosurgery 25:480–494
Wibmer C, Leithner A, Hofmann G, Clar H, Kapitan M, Berghold A et al (2011) Survival analysis of 254 patients after manifestation of spinal metastases: evaluation of seven preoperative scoring systems. Spine 36:1977–1986
pubmed: 21304424
Grosch H, Hoffmann H, Weis C‑A, Thomas M (2016) Thymustumoren. In: Adamietz IA, Bechstein WO, Christiansen H, Doehn C, Hochhaus A, Hofheinz R‑D et al (Hrsg) Weiterbildung Onkologie: CME-Beiträge aus: Der Onkologe Juli 2014 – Dezember 2015. Springer, , S 153–167
Schmidt-Wolf IGH, Rockstroh JK, Schüller H, Hirner A, Grohe C, Müller-Hermelink HK et al (2003) Malignant thymoma: current status of classification and multimodality treatment. Ann Hematol 82:69–76
pubmed: 12601482
Detterbeck FC, Parsons AM. (2004) Thymic tumors. Ann Thorac Surg 77:1860–1869
pubmed: 15111216
de Jong WK, Blaauwgeers JL, Schaapveld M et al (2008) Thymic epithelial tumours: a population-based study of the incidence, diagnostic procedures and therapy. Eur J Cancer 44:123–130
pubmed: 18068351
de Jong WK, Blaauwgeers JLG, Schaapveld M, Timens W, Klinkenberg TJ, Groen HJM (2008) Thymic epithelial tumours: a population-based study of the incidence, diagnostic procedures and therapy. Eur J Cancer 44:123–130
pubmed: 18068351
Scorsetti M, Leo F, Trama A, D’Angelillo R, Serpico D, Macerelli M et al (2016) Thymoma and thymic carcinomas. Crit Rev Oncol Hematol 99:332–350
pubmed: 26818050
Masaoka A, Monden Y, Nakahara K, Tanioka T (1981) Follow-up study of thymomas with special reference to their clinical stages. Cancer 48:2485–2492
pubmed: 7296496
Rosai J, Sobin LH (1999) Histological typing of tumours of the thymus. Springer, Berlin, Heidelberg
McLennan MK (1991) Case report 657: Malignant epithelial thymoma with osteoplastic metastases. Skeletal Radiol 20:141–144
pubmed: 2020863
Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T (2001) Surgical strategy for spinal metastases. Spine 26:298–306
pubmed: 11224867
Rieden K (1988) Knochenmetastasen: Radiologische Diagnostik, Therapie und Nachsorge. Springer, Berlin, Heidelberg
Epidemiologisches Krebsregister NRW. Report 2012 mit Datenbericht 2010
Layer G (2005) Skelettmetastasen. In: Stäbler A (Hrsg) Muskuloskelettales System 2, Springer, Berlin, Heidelberg, S 327–338
Brook RC, Tung K, Oeppen R (2014) Batson’s plexus and retrograde venous spread of malignancy – a pictorial review. Cancer Imaging 14:P40
pmcid: 4242660
Heindel W, Gübitz R, Vieth V, Weckesser M, Schober O, Schäfers M (2014) The diagnostic imaging of bone metastases. Dtsch Arztebl Int 111:741–747
pubmed: 25412631
pmcid: 4239579
Tokuhashi Y, Matsuzaki H, Oda H, Oshima M, Ryu J (2005) A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine 30:2186–2191
pubmed: 16205345
Burgy M, Chenard M‑P, Noel G, Bourahla K, Schott R (2019) Bone metastases from a 1p/19q codeleted and IDH1-mutant anaplastic oligodendroglioma: a case report. J Med Case Reports 13:202
Wu AH, Kaur S, Peng S, Kapoor A, Maroules M (2019) A case of cervical spinal mass with cord compression and rib bone metastasis from presumably burned-out seminomatous testicular germ cell tumor. Can J Urol 26:9799–9801
pubmed: 31180313
Berruti A, Libe R, Lagana M, Ettaieb H, Sukkari MA, Bertherat J et al (2019) Morbidity and mortality of bone metastases in advanced adrenocortical carcinoma: a multicenter retrospective study. Eur J Endocrinol 180:311–320
pubmed: 30970324
Zhang J, Sun Y, Li Z, Feng H (2019) Metastasis of submandibular gland carcinoma to the toe bone: a case report. Br J Oral Maxillofac Surg 57:368–370
pubmed: 30975511
Wejih DM, Leila GE, Ali CM, Ramzi N, Ibtissem B, Chadli D (2019) Rectal stromal tumor with an exceptional liver and bone metastatic locations. Pan Afr Med J 32:133
pubmed: 31303906
pmcid: 6607269
Su Z, Cao X, Zou G (2019) Brain and frontal-bone metastasis from nasopharyngeal carcinoma: case report and literature review. Head Neck. https://doi.org/10.1002/hed.25859
doi: 10.1002/hed.25859
pubmed: 31875340
Zaun G, Schuler M, Herrmann K, Tannapfel A (2018) CUP syndrome-metastatic malignancy with unknown primary tumor. Dtsch Arztebl Int 115:157–162
pubmed: 29587959
pmcid: 5881077
Pavlidis N, Pentheroudakis G (2012) Cancer of unknown primary site. Lancet 379:1428–1435
pubmed: 22414598
Löffler H, Puthenparambil J, Hielscher T, Neben K, Krämer A (2014) Patients with cancer of unknown primary: a retrospective analysis of 223 patients with adenocarcinoma or undifferentiated carcinoma. Dtsch Arztebl Int 111:481–487
pubmed: 25138727
pmcid: 4187410
Delank K‑S, Wendtner C, Eich HT, Eysel P (2011) The treatment of spinal metastases. Dtsch Arztebl Int 108:71–79 (quiz 80)
pubmed: 21311714
pmcid: 3036978
Heary RF, Bono CM (2001) Metastatic spinal tumors. Neurosurg focus 11:e1
pubmed: 16463992
Jarvis J, Garbedian S, Swamy G (2008) Juvenile idiopathic scoliosis: the effectiveness of part-time bracing. Spine 33:1074–1078
pubmed: 18449040
Keller RB (1989) Nonoperative treatment of adolescent idiopathic scoliosis. Instr Course Lect 38:129–135
pubmed: 2649565
Chang V, Holly LT (2014) Bracing for thoracolumbar fractures. Neurosurg focus 37:E3
pubmed: 24981902
Mossa-Basha M, Gerszten PC, Myrehaug S, Mayr NA, Yuh WT, Jabehdar Maralani P et al (2019) Spinal metastasis: diagnosis, management and follow-up. BJR. https://doi.org/10.1259/bjr.20190211
doi: 10.1259/bjr.20190211
pubmed: 31322920
Bartels RHMA, van der Linden YM, van der Graaf WTA (2008) Spinal extradural metastasis: review of current treatment options. CA Cancer J Clin 58:245–259
pubmed: 18354080
van Oorschot B, Höller U, Ottstadt M, Schulze W, Pigorsch S, Riesenbeck D et al (2018) Update – Palliative Strahlentherapie von Knochenmetastasen. Empfehlungen der S3-Leitlinie Supportive Therapie bei onkologischen Patienten. Onkologe 24:253–258. https://doi.org/10.1007/s00761-018-0347-6
doi: 10.1007/s00761-018-0347-6
Schaub SK, Tseng YD, Chang EL, Sahgal A, Saigal R, Hofstetter CP et al (2019) Strategies to mitigate toxicities from stereotactic body radiation therapy for spine metastases. Neurosurgery. https://doi.org/10.1093/neuros/nyz213
doi: 10.1093/neuros/nyz213
pubmed: 31264703
Itshayek E, Yamada J, Bilsky M, Schmidt M, Shaffrey C, Gerszten P et al (2010) Timing of surgery and radiotherapy in the management of metastatic spine disease: a systematic review. Int J Oncol 36(3):533–544
pubmed: 20126972
Schmidt CO, Raspe H, Pfingsten M, Hasenbring M, Basler HD, Eich W et al (2007) Back pain in the German adult population: prevalence, severity, and sociodemographic correlates in a multiregional survey. Spine 32:2005–2011
pubmed: 17700449
Casser H‑R, Seddigh S, Rauschmann M (2016) Acute lumbar back pain. Dtsch Arztebl Int 113:223–234
pubmed: 27120496
pmcid: 4857557
Dt. Ges. f. Orthopädie und orthopäd. Chirurgie + BV d. Ärzte f. Orthopädie (Hrsg.) (2002) Knochenmetastasen. Leitlinien der Orthopädie, 2. Auflage, Dt. Ärzte-Verlag, Köln
Ruffini E, Detterbeck F, van Raemdonck D, Rocco G, Thomas P, Weder W et al (2014) Thymic carcinoma: a cohort study of patients from the European Society of Thoracic Surgeons database. J Thorac Oncol 9:541–548
pubmed: 24736078
Stremmel C, Dango S, Thiemann U, Kayser G, Passlick B (2007) Thymoma—incidence, classification and therapy. Dtsch Med Wochenschr 132:2090–2095
pubmed: 17899505
Weksler B, Dhupar R, Parikh V, Nason KS, Pennathur A, Ferson PF (2013) Thymic carcinoma: a multivariate analysis of factors predictive of survival in 290 patients. Ann Thorac Surg 95:299–303
pubmed: 23141529
Detterbeck F, Youssef S, Ruffini E, Okumura M (2011) A review of prognostic factors in thymic malignancies. J Thorac Oncol 6:1698–1704
Tassi V, Vannucci J, Ceccarelli S, Gili A, Matricardi A, Avenia N et al (2019) Stage-related outcome for thymic epithelial tumours. BMC Surg 18:114
pubmed: 31074388
pmcid: 7402578
Schneiter D, Tomaszek S, Kestenholz P, Hillinger S, Opitz I, Inci I et al (2013) Minimally invasive resection of thymomas with the da Vinci(R) Surgical System. Eur J Cardio thorac Surg 43:288–292
Kondo K, Monden Y (2003) Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan. Ann Thorac Surg 76:878–884 (discussion 884–885)
pubmed: 12963221
Berghmans T, Durieux V, Holbrechts S, Jungels C, Lafitte J‑J, Meert A‑P et al (2018) Systemic treatments for thymoma and thymic carcinoma: a systematic review. Lung Cancer 126:25–31
pubmed: 30527189
Krishnan M, Ganti AK (2019) The role of targeted therapy in thymic carcinoma. J Oncol Pharm Pract. https://doi.org/10.1177/1078155219852758
doi: 10.1177/1078155219852758
pubmed: 31159657
Venuta F, Anile M, Diso D, Vitolo D, Rendina EA, de Giacomo T et al (2010) Thymoma and thymic carcinoma. Eur J Cardio thorac Surg 37:13–25
Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF): Supportive Therapie bei onkologischen PatientInnen -Langversion 1.2, 2019,AWMF Registernummer: 032/054OL, http://leitlinienprogramm-onkologie.de/Supportive-Therapie.95.0.html . Zugegriffen: 21.12.2019
Rechl H, Kirchhoff C, Wörtler K, Lenze U, Töpfer A, von Eisenhart-Rothe R (2011) Diagnostik von malignen Knochen- und Weichteiltumoren. Orthopäde 40:931–941 (quiz 942–943)
pubmed: 21874363
Nystrom JS, Weiner JM, Heffelfinger-Juttner J, Irwin LE, Bateman JR, Wolf RM (1977) Metastatic and histologic presentations in unknown primary cancer. Seminars Oncol 4:53–58