Facile Synthesis of Efficient Luminogens with AIE Features for Three-Photon Fluorescence Imaging of the Brain through the Intact Skull.
NIR-II excitation
aggregation-induced emission
cerebral thrombosis
intact skull
three-photon fluorescence imaging
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
16
01
2020
revised:
30
03
2020
accepted:
02
04
2020
pubmed:
1
5
2020
medline:
7
4
2021
entrez:
1
5
2020
Statut:
ppublish
Résumé
Visualization of the brain in its native environment is important for understanding common brain diseases. Herein, bright luminogens with remarkable aggregation-induced emission (AIE) characteristics and high quantum yields of up to 42.6% in the solid state are synthesized through facile reaction routes. The synthesized molecule, namely BTF, shows ultrabright far-red/near-infrared emission and can be fabricated into AIE dots by a simple nanoprecipitation procedure. Due to their high brightness, large Stokes shift, good biocompatibility, satisfactory photostability, and large three-photon absorption cross section, the AIE dots can be utilized as efficient fluorescent nanoprobes for in vivo brain vascular imaging through the intact skull by a three-photon fluorescence microscopy imaging technique. This is the first example of using AIE dots for the visualization of the cerebral stroke process through the intact skull of a mouse with high penetration depth and good image contrast. Such good results are anticipated to open up a new venue in the development of efficient emitters with strong nonlinear optical effects for noninvasive bioimaging of living brain.
Identifiants
pubmed: 32350951
doi: 10.1002/adma.202000364
doi:
Substances chimiques
Luminescent Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000364Subventions
Organisme : National Natural Science Foundation of China
ID : 21971265
Organisme : National Natural Science Foundation of China
ID : 21374136
Organisme : National Natural Science Foundation of China
ID : 61975172
Organisme : National Natural Science Foundation of China
ID : 61735016
Organisme : National Natural Science Foundation of China
ID : 21788102
Organisme : Fundamental Research Funds for the Central Universities
ID : 18lgpy04
Organisme : Fundamental Research Funds for the Central Universities
ID : 17lgjc03
Organisme : Natural Science Foundation of Zhejiang Province
ID : LR17F050001
Organisme : Research Grants Council of Hong Kong
ID : C6009-17G
Organisme : Innovation and Technology Commission
ID : ITC-CNERC14SC01
Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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