Role of cancer stem cells in the development of giant cell tumor of bone.
Cancer stem cells
Giant cell tumor
Giant cell tumor of bone
Giant cell tumor stromal cells
Mesenchymal stem cells
MicroRNAs
Journal
Cancer cell international
ISSN: 1475-2867
Titre abrégé: Cancer Cell Int
Pays: England
ID NLM: 101139795
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
11
2019
accepted:
17
04
2020
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
1
5
2020
Statut:
epublish
Résumé
The primary bone tumor is usually observed in adolescence age group which has been shown to be part of nearly 20% of the sarcomas known today. Giant cell tumor of bone (GCTB) can be benign as well as malignant tumor which exhibits localized dynamism and is usually associated with the end point of a long bone. Giant cell tumor (GCT) involves mononuclear stromal cells which proliferate at a high rate, multinucleated giant cells and stromal cells are equally present in this type of tumor. Cancer stem cells (CSCs) have been confirmed to play a potential role in the development of GCT. Cancer stem cell-based microRNAs have been shown to contribute to a greater extent in giant cell tumor of bone. CSCs and microRNAs present in the tumors specifically are a great concern today which need in-depth knowledge as well as advanced techniques to treat the bone cancer effectively. In this review, we attempted to summarize the role played by cancer stem cells involving certain important molecules/factors such as; Mesenchymal Stem Cells (MSCs), miRNAs and signaling mechanism such as; mTOR/PI3K-AKT, towards the formation of giant cell tumor of bone, in order to get an insight regarding various effective strategies and research advancements to obtain adequate knowledge related to CSCs which may help to focus on highly effective treatment procedures for bone tumors.
Identifiants
pubmed: 32351329
doi: 10.1186/s12935-020-01218-7
pii: 1218
pmc: PMC7183664
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
135Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
Références
BMB Rep. 2017 Jun;50(6):285-298
pubmed: 28270302
Onco Targets Ther. 2018 Jul 06;11:3891-3900
pubmed: 30013369
Am J Clin Pathol. 2006 Apr;125(4):555-81
pubmed: 16627266
Pediatr Rev. 2018 Sep;39(9):444-453
pubmed: 30171055
Cureus. 2015 Jul 30;7(7):e291
pubmed: 26251767
Surg Pathol Clin. 2017 Sep;10(3):553-573
pubmed: 28797502
J Cancer. 2017 May 12;8(8):1378-1394
pubmed: 28638452
Int J Mol Sci. 2018 Jan 25;19(2):
pubmed: 29370110
Biochim Biophys Acta. 2014 Apr;1845(2):221-31
pubmed: 24480319
Nat Rev Cancer. 2015 Jan;15(1):7-24
pubmed: 25533673
Cells. 2019 Aug 05;8(8):
pubmed: 31530793
Biomed Res Int. 2014;2014:432652
pubmed: 25045675
Tech Orthop. 2018 Sep;33(3):175-182
pubmed: 30636842
Clin Cancer Res. 2017 Nov 1;23(21):6629-6639
pubmed: 28821555
Mol Pharm. 2017 Nov 6;14(11):4113-4120
pubmed: 28954509
J Exp Clin Cancer Res. 2019 Oct 28;38(1):429
pubmed: 31660998
Pharmacol Ther. 2016 Apr;160:145-58
pubmed: 26899500
Orthop Surg. 2016 May;8(2):212-9
pubmed: 27384730
Am J Cancer Res. 2015 Apr 15;5(5):1602-9
pubmed: 26175931
CA Cancer J Clin. 2014 Mar-Apr;64(2):83-103
pubmed: 24488779
Cell Signal. 2014 Jan;26(1):149-61
pubmed: 24140475
Biomed Res Int. 2017;2017:3173547
pubmed: 28589137
Cancers (Basel). 2019 May 13;11(5):
pubmed: 31086012
Front Immunol. 2019 Mar 07;10:375
pubmed: 30899258
Cancer Cell. 2009 Jul 7;16(1):21-32
pubmed: 19573809
Nat Biotechnol. 2011 May;29(5):443-8
pubmed: 21490602
Nat Rev Cancer. 2009 Aug;9(8):550-62
pubmed: 19629070
BMC Cell Biol. 2010 May 08;11:32
pubmed: 20459680
Stem Cells. 2013 Jul;31(7):1227-36
pubmed: 23653415
Mod Pathol. 2010 Mar;23(3):359-66
pubmed: 20062006
Cureus. 2019 Jan 31;11(1):e3989
pubmed: 30972268
Pathol Oncol Res. 2019 Jan;25(1):409-419
pubmed: 29159783
Cell Death Dis. 2018 Feb 20;9(3):299
pubmed: 29463803
Adv Exp Med Biol. 2015;889:201-30
pubmed: 26659003
Int J Biochem Cell Biol. 2018 Jun;99:203-210
pubmed: 29673878
Cell Rep. 2015 Dec 1;13(9):1937-48
pubmed: 26628365
Exp Hematol. 2008 Oct;36(10):1354-1369
pubmed: 18657893
Stem Cells Int. 2016;2016:9451492
pubmed: 26798367
Oncogene. 2017 Aug 24;36(34):4887-4900
pubmed: 28436947
BMC Cancer. 2014 Jul 09;14:495
pubmed: 25005035
Cancer Lett. 2012 Aug 28;321(2):162-8
pubmed: 22326282
Semin Diagn Pathol. 2018 Jan;35(1):20-33
pubmed: 29150219
Semin Diagn Pathol. 2011 Feb;28(1):86-101
pubmed: 21675380
PLoS One. 2015 May 01;10(5):e0125316
pubmed: 25933380
Sci Rep. 2019 Jul 17;9(1):10332
pubmed: 31316122
Recent Results Cancer Res. 2015;200:195-224
pubmed: 26376878
Cell Cycle. 2008 Apr 15;7(8):965-70
pubmed: 18414037
J Lipid Res. 2019 Jul;60(7):1225-1235
pubmed: 30988134
Int J Stem Cells. 2014 Nov;7(2):118-26
pubmed: 25473449
Hum Pathol. 2018 Nov;81:1-8
pubmed: 29944971
Curr Cancer Drug Targets. 2019;19(5):360-367
pubmed: 29968537
Stem Cells Int. 2018 Aug 19;2018:8031718
pubmed: 30210552
Oncotarget. 2017 Jun 28;8(49):85040-85053
pubmed: 29156702
Oncologist. 2014 May;19(5):550-61
pubmed: 24718514
EMBO Rep. 2014 Mar;15(3):244-53
pubmed: 24531722
Sci Rep. 2018 Aug 9;8(1):11935
pubmed: 30093656
J Cell Sci. 2018 Jun 5;131(11):
pubmed: 29871956
Biomed Res Int. 2014;2014:903542
pubmed: 25025074
Open Orthop J. 2013 May 03;7:109-13
pubmed: 23730372
Oxid Med Cell Longev. 2018 Oct 30;2018:7838647
pubmed: 30510625
Oncol Lett. 2018 Oct;16(4):4649-4655
pubmed: 30214599
Rev Bras Ortop. 2017 Jun 27;52(4):473-478
pubmed: 28884107
Curr Stem Cell Res Ther. 2019;14(5):421-427
pubmed: 30806324
Nat Rev Rheumatol. 2013 Oct;9(10):584-94
pubmed: 23881068
Cell. 2017 Aug 10;170(4):605-635
pubmed: 28802037
World J Biol Chem. 2017 Feb 26;8(1):45-56
pubmed: 28289518
Lab Invest. 2019 Apr;99(4):483-498
pubmed: 30487595
Stem Cells Int. 2016;2016:4810734
pubmed: 27843459
Korean J Intern Med. 2013 Jul;28(4):387-402
pubmed: 23864795
Cell Cycle. 2008 Aug 15;7(16):2466-71
pubmed: 18719377
Am J Transl Res. 2017 Dec 15;9(12):5743-5753
pubmed: 29312525
Cell Death Differ. 2008 Mar;15(3):504-14
pubmed: 18049477
J Neurooncol. 2011 Sep;104(2):509-22
pubmed: 21336775
J Cancer Res Clin Oncol. 2018 Apr;144(4):617-627
pubmed: 29417259
Pharmacol Ther. 2018 Jul;187:13-30
pubmed: 29421575
J Clin Med. 2017 Dec 22;7(1):
pubmed: 29271928
PLoS One. 2013 Jul 26;8(7):e69101
pubmed: 23922683
J Surg Oncol. 2012 Dec;106(7):826-36
pubmed: 22605660
Cancer Lett. 2017 Nov 28;409:49-55
pubmed: 28866093
Cells. 2019 Apr 09;8(4):
pubmed: 30970654
BMC Syst Biol. 2013;7 Suppl 2:S12
pubmed: 24564919
JAMA Pediatr. 2013 Aug 1;167(8):700-7
pubmed: 23754213
Oncol Lett. 2012 Dec;4(6):1264-1268
pubmed: 23197999
Cancers (Basel). 2018 Apr 15;10(4):
pubmed: 29662021
Cancer Lett. 2016 Feb 1;371(1):134-41
pubmed: 26655997
Int J Clin Exp Pathol. 2015 Aug 01;8(8):9718-22
pubmed: 26464744
Cancer Chemother Pharmacol. 2017 Dec;80(6):1113-1131
pubmed: 29038849
Drug Discov Today. 2014 Oct;19(10):1547-62
pubmed: 24819719
Hum Pathol. 2003 Oct;34(10):983-93
pubmed: 14608531
Cell. 2017 Apr 20;169(3):381-405
pubmed: 28431241
Oncogene. 2014 Oct 16;33(42):4967-77
pubmed: 24240682
J Orthop Res. 2005 Sep;23(5):979-87
pubmed: 16024207
Cell Death Dis. 2014 Oct 16;5:e1471
pubmed: 25321478
Oncotarget. 2015 Aug 7;6(22):18980-96
pubmed: 26053181
J Cell Biochem. 2018 Jul;119(7):5805-5812
pubmed: 29600575
PLoS One. 2014 Jun 16;9(6):e99143
pubmed: 24932611
Clin Chim Acta. 2015 Apr 15;444:182-92
pubmed: 25704303
Case Rep Radiol. 2016;2016:9786925
pubmed: 27630783
Eur J Cancer. 2017 May;77:75-83
pubmed: 28365529
Clin Orthop Relat Res. 2007 Jun;459:8-13
pubmed: 17327805
Cell Mol Life Sci. 2019 Oct;76(20):4043-4070
pubmed: 31317205
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018 Jan 1;32(1):31-35
pubmed: 29806361
Int J Oncol. 2015 Sep;47(3):909-17
pubmed: 26202311
Stem Cells Dev. 2014 Jul 15;23(14):1611-24
pubmed: 24650034
Exp Biol Med (Maywood). 2015 Feb;240(2):185-93
pubmed: 25294891
Oncol Lett. 2016 Dec;12(6):4312-4318
pubmed: 28101196
Breast Cancer Res. 2016 May 24;18(1):55
pubmed: 27220421
Cancer Epidemiol. 2016 Jun;42:82-9
pubmed: 27060625
Curr Top Microbiol Immunol. 2010;347:1-19
pubmed: 20549473
Radiology. 2010 Jun;255(3):967-78
pubmed: 20501734
Nat Rev Mol Cell Biol. 2012 Apr 04;13(5):283-96
pubmed: 22473468
Biologics. 2015 Jul 14;9:69-74
pubmed: 26203221
Clin Orthop Surg. 2012 Jun;4(2):107-16
pubmed: 22662295
Pediatr Blood Cancer. 2018 Apr;65(4):
pubmed: 29286564
Int J Mol Sci. 2019 Feb 11;20(3):
pubmed: 30754640
Cancers (Basel). 2018 Mar 18;10(3):
pubmed: 29562639
World J Stem Cells. 2019 Jun 26;11(6):347-374
pubmed: 31293717
Am J Cancer Res. 2018 Apr 01;8(4):662-674
pubmed: 29736311
Oncogene. 2014 Jan 2;33(1):116-28
pubmed: 23524583
Gulf J Oncolog. 2019 May;1(30):67-75
pubmed: 31242985
Theranostics. 2019 May 31;9(15):4265-4286
pubmed: 31285761
Biol Rev Camb Philos Soc. 2017 Aug;92(3):1505-1520
pubmed: 27545872
J Cancer. 2017 Feb 11;8(3):469-478
pubmed: 28261349
Oncotarget. 2017 Mar 28;8(13):22203-22217
pubmed: 28108737
Stem Cell Rev Rep. 2018 Jun;14(3):309-322
pubmed: 29541978
Acta Orthop Traumatol Turc. 2019 Jan;53(1):35-39
pubmed: 30392920
Theranostics. 2015 Apr 05;5(7):733-45
pubmed: 25897338
J Bone Miner Res. 2014 Jan;29(1):78-89
pubmed: 23821483
Chin J Cancer. 2013 May;32(5):253-65
pubmed: 23642907