Spinal Cord Injury as a Model of Bone-Muscle Interactions: Therapeutic Implications From
bone
bone loss
muscle
osteoporosis
rehabilitation
sarcopenia
spinal cord injury
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
12
2019
accepted:
23
03
2020
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
29
5
2021
Statut:
epublish
Résumé
Spinal cord injuries (SCIs) represent a variety of conditions related to the damage of the spinal cord with consequent musculoskeletal repercussions. The bone and muscle tissues share several catabolic pathways that lead to variable degrees of disability in SCI patients. In this review article, we provide a comprehensive characterization of the available treatment options targeting the skeleton and the bone in the setting of SCI. Among the pharmacological intervention, bisphosphonates, anti-sclerostin monoclonal antibodies, hydrogen sulfide, parathyroid hormone, and RANKL pathway inhibitors represent valuable options for treating bone alterations. Loss phenomena at the level of the muscle can be counteracted with testosterone, anabolic-androgenic steroids, and selective androgen receptor modulators. Exercise and physical therapy are valuable strategies to increase bone and muscle mass. Nutritional interventions could enhance SCI treatment, particularly in the setting of synergistic and multidisciplinary interventions, but there are no specific guidelines available to date. The development of multidisciplinary recommendations is required for a proper clinical management of SCI patients.
Identifiants
pubmed: 32351450
doi: 10.3389/fendo.2020.00204
pmc: PMC7174687
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
204Informations de copyright
Copyright © 2020 Invernizzi, de Sire, Renò, Cisari, Runza, Baricich, Carda and Fusco.
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