The Effect of Lymph Nodes' Histologic Response on Survival Outcomes in Moroccan Patients with Rectal Cancer.
Adult
Aged
Aged, 80 and over
Carcinoma
/ mortality
Chemoradiotherapy, Adjuvant
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Lymph Node Excision
Lymph Nodes
/ pathology
Male
Middle Aged
Morocco
Neoadjuvant Therapy
Proctectomy
Prognosis
Rectal Neoplasms
/ mortality
Retrospective Studies
Survival Analysis
Young Adult
Journal
International journal of surgical oncology
ISSN: 2090-1410
Titre abrégé: Int J Surg Oncol
Pays: United States
ID NLM: 101566285
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
10
2019
revised:
15
11
2019
accepted:
10
12
2019
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Prognosis for patients with locally advanced rectal cancer remains controversial. The purpose of this study was to elucidate possible association between therapeutic effect on lymph nodes (LNs) and patient prognosis. Overall, 149 patients with rectal cancer received preoperative radiotherapy in concomitance with chemotherapy or exclusive radiotherapy before rectal excision. Microscopic examination of formalin-fixed lymph nodes was assessed for therapeutic effect. The establishment of groups combined reaction tissue types of fibrosis, colloid, and necrosis after neoadjuvant treatment was assigned. The average age was 56.38 years, ranged between 22 and 88 years, 53% were female, and 47% were men, with a sex ratio of 1 : 12. In the present study, we noticed that after a median follow-up time of 40.67 months (0-83; SD: 21.1), overall survival was statistically significant depending on age groups. Kaplan-Meier analysis showed significant differences in the rate of patients with an age under 65 years (70.64%) versus those with an age over 85 years (36.5%) (
Identifiants
pubmed: 32351736
doi: 10.1155/2020/8406045
pmc: PMC7183526
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8406045Informations de copyright
Copyright © 2020 Ihsane El Otmani et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this paper.
Références
Ann Surg. 2009 Oct;250(4):582-9
pubmed: 19710605
J Clin Oncol. 2011 Dec 1;29(34):4568-73
pubmed: 21990400
Int J Cancer. 2019 Apr 15;144(8):1941-1953
pubmed: 30350310
Ann Surg Oncol. 2016 Nov;23(12):3899-3906
pubmed: 27380639
J Clin Oncol. 2005 Dec 1;23(34):8688-96
pubmed: 16246976
JAMA Surg. 2015 Mar 1;150(3):260-6
pubmed: 25629513
J Am Coll Surg. 1995 Mar;180(3):297-306
pubmed: 7874340
N Engl J Med. 2004 Oct 21;351(17):1731-40
pubmed: 15496622
Hum Pathol. 2012 Nov;43(11):1917-23
pubmed: 22575264
Cancer Res Treat. 2016 Jul;48(3):998-1009
pubmed: 26511803
Am J Clin Oncol. 1993 Jun;16(3):223-8
pubmed: 8338056
CA Cancer J Clin. 2017 Mar;67(2):93-99
pubmed: 28094848
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Oncotarget. 2016 Apr 19;7(16):22497-507
pubmed: 26992210
J Clin Oncol. 1999 Aug;17(8):2396
pubmed: 10561302
Int J Colorectal Dis. 1997;12(1):19-23
pubmed: 9112145
Cancer. 1994 Jun 1;73(11):2680-6
pubmed: 8194005
Dis Colon Rectum. 2004 Mar;47(3):279-86
pubmed: 14991488
Int J Cancer. 2014 Jul 15;135(2):371-8
pubmed: 24921087
Histopathology. 2005 Aug;47(2):141-6
pubmed: 16045774