Identification and Analysis of Components in Yizhi Granule and Cynomolgus Monkey Plasma after Oral Administration by UPLC/ESI-Q-TOF MS and Their Protective Effects on PC12 Cells.
Journal
Journal of analytical methods in chemistry
ISSN: 2090-8865
Titre abrégé: J Anal Methods Chem
Pays: Egypt
ID NLM: 101575377
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
12
2019
accepted:
28
01
2020
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
1
5
2020
Statut:
epublish
Résumé
Yizhi Granule (YZG) is a health food containing six traditional Chinese medicines (TCMs). It improves memory barriers in rat experiments. Here, we describe the first fast and sensitive ultraperformance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC/ESI-Q-TOF MS) method for analyzing YZG in plasma. We used this technique for studies in cynomolgus monkey plasma. By comparing retention time, MS, and MS/MS data of reference compounds, 70 compounds were detected in YZG. Of these, 63 were identified including 60 saponins, 2 flavones, and 1 methyl ester. There were 33 saponins, 1 flavone, and 1 methyl ester in the plasma. Next, to study the therapeutic properties of YZG, the neuroprotective effect of some of the absorbed components was evaluated using PC12 cell damage caused by the A
Identifiants
pubmed: 32351755
doi: 10.1155/2020/5165631
pmc: PMC7171651
doi:
Types de publication
Journal Article
Langues
eng
Pagination
5165631Informations de copyright
Copyright © 2020 Erwei Hao et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Nat Prod Res. 2017 May;31(10):1107-1112
pubmed: 27558291
Phytochem Anal. 2015 Mar-Apr;26(2):145-60
pubmed: 25448530
Alzheimers Dement. 2014 Jan;10(1):1-9
pubmed: 23871765
Neurochem Res. 2018 Aug;43(8):1529-1538
pubmed: 29926354
Int J Geriatr Psychiatry. 2013 Mar;28(3):256-64
pubmed: 23386588
FASEB J. 2009 Oct;23(10):3315-24
pubmed: 19487308
Mol Med Rep. 2019 Apr;19(4):2975-2998
pubmed: 30816465
Oxid Med Cell Longev. 2017;2017:4176518
pubmed: 29085554
J Ethnopharmacol. 2015 May 13;165:127-40
pubmed: 25698242
J Ginseng Res. 2018 Oct;42(4):401-411
pubmed: 30337800
Food Chem. 2016 Dec 1;212:250-5
pubmed: 27374530
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:62-73
pubmed: 26896573
Neurosci Lett. 2006 May 15;399(1-2):91-5
pubmed: 16490313
J Ethnopharmacol. 2014 May 14;153(3):701-13
pubmed: 24661968
Chin J Nat Med. 2015 Jun;13(6):471-80
pubmed: 26073345
Biomed Res Int. 2017;2017:7464872
pubmed: 29057264
Evid Based Complement Alternat Med. 2015;2015:235265
pubmed: 25705234
J Alzheimers Dis. 2011;24(1):77-84
pubmed: 21383494
J Health Hum Serv Adm. 2007 Winter;30(3):292-305
pubmed: 18236705
J Drug Target. 2018 Feb;26(2):182-193
pubmed: 28697660
Arch Pharm Res. 2017 Mar;40(3):338-349
pubmed: 28093699
Eur Arch Psychiatry Clin Neurosci. 1996;246(3):124-8
pubmed: 8739396
Behav Brain Res. 2018 Jan 30;337:160-172
pubmed: 28927718
Zhongguo Zhong Yao Za Zhi. 2007 Mar;32(5):365-70
pubmed: 17511134
Phytochemistry. 2018 Feb;146:16-24
pubmed: 29207319
EMBO Mol Med. 2016 Jun 01;8(6):595-608
pubmed: 27025652
Comput Struct Biotechnol J. 2018 Nov 14;16:523-531
pubmed: 30524667
Alzheimers Dement. 2018 Apr;14(4):483-491
pubmed: 29433981
Anim Cells Syst (Seoul). 2018 Sep 05;22(5):305-316
pubmed: 30460112
J Alzheimers Dis. 2018;64(1):309-322
pubmed: 29865080
J Med Food. 2016 Oct;19(10):901-911
pubmed: 27654707
Brain Res Brain Res Rev. 1995 Sep;21(2):195-218
pubmed: 8866675
Brain Res. 2018 Jan 1;1678:187-194
pubmed: 29038007
Eur J Pharmacol. 2019 Jan 5;842:365-372
pubmed: 30412728
J Immunotoxicol. 2005 Oct 1;2(4):211-6
pubmed: 18958676
J Nat Prod. 2002 Mar;65(3):346-51
pubmed: 11908976
Alzheimer Dis Assoc Disord. 2006 Apr-Jun;20(2 Suppl 1):S12-8
pubmed: 16772751