Effects of Low-Dose Gamma-Ray Radiation on Apoptosis and Development of Zebrafish Embryo Brain.

Animals Apoptosis / radiation effects Brain / cytology Dose-Response Relationship, Radiation Gamma Rays / adverse effects Gene Expression Regulation, Developmental / radiation effects Risk Assessment Zebrafish / embryology

Journal

Radiation research
ISSN: 1938-5404
Titre abrégé: Radiat Res
Pays: United States
ID NLM: 0401245

Informations de publication

Date de publication:
08 07 2020
Historique:
received: 01 05 2019
accepted: 27 03 2020
pubmed: 1 5 2020
medline: 15 12 2020
entrez: 1 5 2020
Statut: ppublish

Résumé

To investigate the effects of low-dose γ irradiation on apoptosis and development of the brain in zebrafish embryos, cumulative 15 mGy doses of γ rays from a 137Cs source were used to irradiate zebrafish embryos at 2 h post-fertilization (hpf) for 120 h. Apoptosis of the brain, brain morphological development, cell submicroscopic structure and mRNA expression were analyzed, respectively. Results indicate that after 15 mGy exposure, the apoptosis of zebrafish brain increased, vacuoles appeared in brain tissue, some organelles were damaged and vacuoles appeared locally in brain cells. The mRNA expression level of axin2 was significantly upregulated, and those of frizzled, β-catenin, camk2, TCF/ LEF and bcl9 were significantly downregulated in brain tissue. These genes are involved in the Wnt signaling pathway. The findings of this work suggest that low-dose radiation may influence the apoptosis and development of the brain in the zebrafish embryo by inhibiting the Wnt signaling pathway.

Identifiants

DOI: 10.1667/RR15426.1 PMID: 32352865
pubmed: 32352865
pii: 436354
doi: 10.1667/RR15426.1
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

61-70

Informations de copyright

©2020 by Radiation Research Society. All rights of reproduction in any form reserved.

Auteurs

Weichao Zhao (W)

Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang, Hunan 421001, China.
School of Public Health, University of South China, Hunan Hengyang 421001, China.

Penghui Yuan (P)

Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang, Hunan 421001, China.
Hunan Province Key Laboratory of Green Development Technology for Extremely Low Grade Uranium Resources, Hengyang, Hunan 421001, China.

Nan Hu (N)

Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang, Hunan 421001, China.
Hunan Province Key Laboratory of Green Development Technology for Extremely Low Grade Uranium Resources, Hengyang, Hunan 421001, China.

Dingxin Long (D)

School of Public Health, University of South China, Hunan Hengyang 421001, China.

Dexin Ding (D)

Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang, Hunan 421001, China.
Hunan Province Key Laboratory of Green Development Technology for Extremely Low Grade Uranium Resources, Hengyang, Hunan 421001, China.

Huimin Wang (H)

Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy, University of South China, Hengyang, Hunan 421001, China.
Hunan Province Key Laboratory of Green Development Technology for Extremely Low Grade Uranium Resources, Hengyang, Hunan 421001, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Effects of Low-Dose Gamma-Ray Radiation on...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Effects of Low-Dose Gamma-Ray Radiation on...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Effects of Low-Dose Gamma-Ray Radiation on...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Hygiène radiologique › Dose de rayonnement › Relation dose-effet des rayonnements › Effects of Low-Dose Gamma-Ray Radiation on...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement ionisant › Rayons gamma › Effects of Low-Dose Gamma-Ray Radiation on...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Effects of Low-Dose Gamma-Ray Radiation on...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › Effects of Low-Dose Gamma-Ray Radiation on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Effects of Low-Dose Gamma-Ray Radiation on...