Getting in Touch with Mechanical Pain Mechanisms.

Animals Neurons Pain Touch Perception
DRG neuron mechanical pain mechanonociceptor nociception peripheral nervous system somatosensory

Journal

Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616

Informations de publication

Date de publication:
05 2020
Historique:
received: 20 11 2019
revised: 14 02 2020
accepted: 04 03 2020
entrez: 1 5 2020
pubmed: 1 5 2020
medline: 19 8 2021
Statut: ppublish

Résumé

The peripheral somatosensory system bestows mammals with a diverse repertoire of sensory modalities: gentle touch, mechanical pain, itch, thermosensation, and proprioception. The cells and molecules that transduce many of these stimuli have already been characterized. But how somatosensory neurons transduce acutely painful mechanical forces is largely unknown and remains one of the 'final frontiers' of sensory neurobiology. In an effort to fill this gap in knowledge, recent studies have identified subpopulations of mechanical pain neurons and uncovered novel modulators of mechanical pain. These studies have greatly advanced our understanding of how noxious mechanical stimuli are detected in mammals. Here, we discuss recent progress in noxious mechanosensation and highlight new behavioral methods to assess mechanical pain.

Identifiants

DOI: 10.1016/j.tins.2020.03.004 PMID: 32353335
pubmed: 32353335
pii: S0166-2236(20)30050-3
doi: 10.1016/j.tins.2020.03.004
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

311-325

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Rose Z Hill (RZ)

Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA 94703, USA.

Diana M Bautista (DM)

Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA 94703, USA; Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA 94703, USA. Electronic address: dbautista@berkeley.edu.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Getting in Touch with Mechanical Pain Mechanisms.
questionsmedicales.fr › Cellules › Neurones › Getting in Touch with Mechanical Pain Mechanisms.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Getting in Touch with Mechanical Pain Mechanisms.
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception du toucher › Getting in Touch with Mechanical Pain Mechanisms.